4'-METHOXY-5,6-BENZOFLAVONE

Base Information

• Chemical Name: 4'-METHOXY-5,6-BENZOFLAVONE
• CAS No.: 125240-02-0
• Molecular Formula: C20H14O3
• Molecular Weight: 302.329
• Mol file: 125240-02-0.mol

Synonyms:3-(4-Methoxyphenyl)-1H-benzo[f]chromen-1-one;

Chemical Property of 4'-METHOXY-5,6-BENZOFLAVONE

Chemical Property:

• Boiling Point: 490.7 °C at 760 mmHg
• Flash Point: 242.8 °C
• PSA: 39.44000
• Density: 1.273 g/cm³
• LogP: 4.62180
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

99% ^*data from raw suppliers

4''-Methoxy-5,6-benzoflavone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4'-METHOXY-5,6-BENZOFLAVONE

There total 17 articles about 4'-METHOXY-5,6-BENZOFLAVONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-(2-hydroxy-[1]naphthyl)-3-(4-methoxy-phenyl)-propane-1,3-dione (854652-67-8) → UCCF 040 (125240-02-0)

Guidance literature:

With sulfuric acid; In acetic acid; Reflux;

DOI:10.1039/c7md00565b DOI:10.1039/c8md00512e

Reference yield: 65.0%

(E)-1-(2-hydroxynaphthalen-1-yl)-3-(4-methoxyphenyl)prop-2-en-1-one (28656-32-8) → UCCF 040 (125240-02-0)

Guidance literature:

With iodine; In dimethyl sulfoxide; Reflux;

DOI:10.1016/j.ejmech.2013.06.035

Reference yield:

4-methoxy-benzoic acid-(1-acetyl-[2]naphthyl ester) → UCCF 040 (125240-02-0)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH / pyridine / 40 °C

2: sulfuric acid / acetic acid / Heating

With potassium hydroxide; sulfuric acid; In pyridine; acetic acid; 1: mixed-Claisen rearrangement;

DOI:10.1016/S0968-0896(03)00435-8

upstream raw materials:

1-(2-hydroxy-[1]naphthyl)-3-(4-methoxy-phenyl)-propane-1,3-dione

1-(2-hydroxy-1-naphthyl)ethan-1-one

p-Methoxybenzoic anhydride

3-(4-methoxyphenyl)-2,3-dihydro-1H-benzo[f]chromen-1-one

Downstream raw materials:

3-(2-hydroxy-1-naphthyl)-5-(4-methoxy-phenyl)-2-isoxazoline

4'-Hydroxy-beta-naphthoflavone

Refernces

• 1、 Ullal,Shah,Wheeler. "-". . p. 1499. Retrieved 1940.
• 2、 Singh, Jatinder V.,Kaur, Anumeet,Bhagat, Kavita,Gupta, Manish K.,Singh, Manwinder,Singh, Harbinder,Bedi, Preet Mohinder S.. "5,6-Benzoflavones as cholesterol esterase inhibitors: Synthesis, biological evaluation and docking studies". . p. 490 - 502. Retrieved 2018/03/28.