3,7,3',4'-TETRAMETHYLGOSSYPETIN

Base Information

• Chemical Name: 3,7,3',4'-TETRAMETHYLGOSSYPETIN
• CAS No.: 7380-44-1
• Molecular Formula: C19H18 O8
• Molecular Weight: 374.347
• Mol file: 7380-44-1.mol

Synonyms:Flavone,5,8-dihydroxy-3,3',4',7-tetramethoxy- (6CI,7CI,8CI); 5,8-Dihydroxy-3,7,3',4'-tetramethoxyflavone;Gossypetin 3,3',4',7-O-tetramethyl ether

Chemical Property of 3,7,3',4'-TETRAMETHYLGOSSYPETIN

Chemical Property:

• Vapor Pressure: 2.41E-14mmHg at 25°C
• Melting Point: 250-252 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 586.3°C at 760 mmHg
• PKA: 6.86±0.40(Predicted)
• Flash Point: 215.8°C
• PSA: 107.59000
• Density: 1.387g/cm³
• LogP: 2.90560

Purity/Quality:

98%min ^*data from raw suppliers

5,8-Dihydroxy-3,3',4',7-tetramethoxyflavone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,7,3',4'-TETRAMETHYLGOSSYPETIN

There total 8 articles about 3,7,3',4'-TETRAMETHYLGOSSYPETIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

retusin (1245-15-4) → 5,8-dihydroxy-3,7-dimethoxy-2-(3,4-dimethoxyphenyl)-4-benzopyrone (7380-44-1)

Guidance literature:

With 3,3-dimethyldioxirane; In dichloromethane; acetone; at 0 - 20 ℃; for 0.833333h;

DOI:10.1016/j.tet.2004.01.023

Reference yield:

2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-4H-chromen-4-one (855-97-0) → 5,8-dihydroxy-3,7-dimethoxy-2-(3,4-dimethoxyphenyl)-4-benzopyrone (7380-44-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 86 percent / dimethyl dioxirane / acetone; CH₂Cl₂ / 0.5 h / 0 - 20 °C

2: 96 percent / K₂CO₃ / acetone / 1 h / Heating

3: 99 percent / BBr₃ / CH₂Cl₂ / 0.5 h / 0 °C

4: 89 percent / dimethyl dioxirane / acetone; CH₂Cl₂ / 0.83 h / 0 - 20 °C

With 3,3-dimethyldioxirane; boron tribromide; potassium carbonate; In dichloromethane; acetone;

DOI:10.1016/j.tet.2004.01.023

Reference yield:

2'-hydroxy-3,4,4',6'-tetramethoxychalcone (114021-60-2) → 5,8-dihydroxy-3,7-dimethoxy-2-(3,4-dimethoxyphenyl)-4-benzopyrone (7380-44-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 97 percent / K₂CO₃ / acetone / 2 h / Heating

2: 86 percent / dimethyl dioxirane / acetone; CH₂Cl₂ / 0.5 h / 0 - 20 °C

3: 96 percent / K₂CO₃ / acetone / 1 h / Heating

4: 99 percent / BBr₃ / CH₂Cl₂ / 0.5 h / 0 °C

5: 89 percent / dimethyl dioxirane / acetone; CH₂Cl₂ / 0.83 h / 0 - 20 °C

With 3,3-dimethyldioxirane; boron tribromide; potassium carbonate; In dichloromethane; acetone;

DOI:10.1016/j.tet.2004.01.023

upstream raw materials:

retusin

2'-hydroxy-3,4,4',6'-tetramethoxychalcone

5-hydroxy-3',4',7-trimethoxyflavone

2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-4H-chromen-4-one

Downstream raw materials:

8-benzyloxy-2-(3,4-dimethoxy-phenyl)-5-hydroxy-3,7-dimethoxy-chromen-4-one

8-ethoxy-2-(3,4-dimethoxy-phenyl)-5-hydroxy-3,7-dimethoxy-chromen-4-one

hexa-O-methylogossypetin

2-(3,4-dimethoxy-phenyl)-5,6,8-trihydroxy-3,7-dimethoxy-chromen-4-one

Refernces

• 1、 Manthey, John A.,Guthrie, Najla. "Antiproliferative activities of citrus flavonoids against six human cancer cell lines". . p. 5837 - 5843. Retrieved 2007/10/03.