4-Chloro-N-methylbenzenesulphonamide

Base Information

• Chemical Name: 4-Chloro-N-methylbenzenesulphonamide
• CAS No.: 6333-79-5
• Molecular Formula: C7H8ClNO2S
• Molecular Weight: 205.665
• Hs Code.: 2935009090
• Mol file: 6333-79-5.mol

Synonyms:Benzenesulfonamide,p-chloro-N-methyl- (7CI,8CI);4-Chloro-N-methylbenzenesulfonamide;N-Methyl-4-chlorobenzenesulfonamide;N-Methyl-p-chlorobenzenesulfonamide;NSC31051;NSC 404320;

Chemical Property of 4-Chloro-N-methylbenzenesulphonamide

Chemical Property:

• Vapor Pressure: 0.000528mmHg at 25°C
• Melting Point: 52-54 °C
• Refractive Index: 1.553
• Boiling Point: 312.5 °C at 760 mmHg
• PKA: 11.10±0.30(Predicted)
• Flash Point: 142.8 °C
• PSA: 54.55000
• Density: 1.353 g/cm³
• LogP: 2.71980
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Acetonitrile (Slightly), Chloroform (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

4-Chloro-N-methylbenzenesulphonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Chloro-N-methylbenzenesulphonamide can be used as a iridium catalyst.

Technology Process of 4-Chloro-N-methylbenzenesulphonamide

There total 20 articles about 4-Chloro-N-methylbenzenesulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanol (67-56-1) + 4-Chlorobenzenesulfonamide (98-64-6) → 4-chloro-N-methylbenzenesulfonamide (6333-79-5)

Guidance literature:

With [(N,N′-bis(diisopropylphosphino)-2,6-diaminopyridine)Mn(CO)₃][Br]; potassium tert-butylate; In toluene; at 120 ℃; for 60h; Inert atmosphere; Glovebox; Schlenk technique;

DOI:10.1016/j.jcat.2017.01.004

Reference yield: 98.0%

4-chlorobenzenesulfonyl chloride (98-60-2) + methylamine (74-89-5) → 4-chloro-N-methylbenzenesulfonamide (6333-79-5)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 0.25h;

DOI:10.1002/ejoc.201501032

Reference yield: 95.0%

succinic acid anhydride (108-30-5) + 4-Chlorobenzenesulfonamide (98-64-6) + methyl iodide (74-88-4) → 4-chloro-N-methylbenzenesulfonamide (6333-79-5)

Guidance literature:

Multistep reaction.;

DOI:10.1021/ol0163124

upstream raw materials:

4-chlorobenzenesulfonyl chloride

methylamine

4-Chlorobenzenesulfonamide

dimethyl sulfate

Downstream raw materials:

4-chloro-N-methyl-N-(2-phenylimidazo[1,2-a]pyridin-3-yl)benzenesulfonamide

Refernces

• 1、 Liu, Peng,Tung, Nguyen Thanh,Xu, Xiangchao,Yang, Jiazhi,Li, Feng. "N-Methylation of Amines with Methanol in the Presence of Carbonate Salt Catalyzed by a Metal-Ligand Bifunctional Ruthenium Catalyst [(p-cymene)Ru(2,2′-bpyO)(H2O)]". . p. 2621 - 2631. Retrieved 2021/02/27.
• 2、 Liu, Xiang,Loh, Teck-Peng,Qiang, Wenwen,Wang, Jing,Ye, Sen,Zhu, Longfei. "Additive-freeN-methylation of amines with methanol over supported iridium catalyst". . p. 3364 - 3375. Retrieved 2021/06/06.