4-Trifluoromethyl-benzamidine

Base Information

• Chemical Name: 4-Trifluoromethyl-benzamidine
• CAS No.: 131472-28-1
• Molecular Formula: C8H7F3N2
• Molecular Weight: 188.152
• Hs Code.: 2925290090
• Mol file: 131472-28-1.mol

Synonyms:4-Trifluoromethylbenzamidine;

Chemical Property of 4-Trifluoromethyl-benzamidine

Chemical Property:

• Vapor Pressure: 0.164mmHg at 25°C
• Refractive Index: 1.493
• Boiling Point: 213.4 °C at 760 mmHg
• Flash Point: 82.9 °C
• PSA: 49.87000
• Density: 1.33g/cm³
• LogP: 2.78950
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

4-(Trifluoromethyl)benzene-1-carboximidamide 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Trifluoromethyl-benzamidine

There total 7 articles about 4-Trifluoromethyl-benzamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-hydroxy-4-(trifluoromethyl)benzimidamide (22179-86-8) → 4-trifluoromethylbenzamidine (131472-28-1)

Guidance literature:

With palladium 10% on activated carbon; ammonium formate; acetic acid; for 10h; Reflux; Inert atmosphere;

Reference yield: 80.0%

4-(trifluoromethyl)benzamidoxime (22179-86-8) → 4-trifluoromethylbenzamidine (131472-28-1)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In acetic acid; for 4h; Heating;

DOI:10.1055/s-2003-42410

Reference yield: 57.9%

4-CF3C6H4CN (455-18-5) → 4-trifluoromethylbenzamidine (131472-28-1)

Guidance literature:

4-CF₃C₆H₄CN; With lithium bis(trimethylsilyl)amide diethyl etherate; In diethyl ether; Inert atmosphere;

With hydrogenchloride; In diethyl ether; ethanol; water; Inert atmosphere;

With sodium hydroxide; In water; Inert atmosphere;

DOI:10.1021/ic2003996

upstream raw materials:

3-chloro-3-(4-trifluoromethylphenyl)diaziridine

sodium thiophenolate

3-(p-(trifluoromethyl)phenyl)diazirine

4-(trifluoromethyl)benzenimidic acid ethyl ester hydrochloride

Downstream raw materials:

C₁₀H₇F₆N₃

C₁₀H₇F₆N₃*ClH

C₁₀H₄ClF₆N₃S

C₁₀H₄F₆N₃S

Refernces

• 1、 Lu, Xiaodong,Xin, Xiaoyi,Wan, Boshun. "Silver-catalyzed [3+2+1] annulation of aryl amidines with benzyl isocyanide". . p. 361 - 364. Retrieved 2018/01/08.
• 2、 Boere, Rene T.,Roemmele, Tracey L.,Yu, Xin. "Unsymmetrical 1α3-1,2,4,6-thiatriazinyls with aryl and trifluoromethyl substituents: Synthesis, crystal structures, EPR spectroscopy, and voltammetry". experimental part. p. 5123 - 5136. Retrieved 2011/08/03.