3-BUTYL-1,5-DIPHENYL-1H-PYRAZOLE

Base Information

• Chemical Name: 3-BUTYL-1,5-DIPHENYL-1H-PYRAZOLE
• CAS No.: 871110-25-7
• Molecular Formula: C₁₉H₂₀N₂
• Molecular Weight: 276.381
• Mol file: 871110-25-7.mol

Synonyms:1H-Pyrazole,3-butyl-1,5-diphenyl;3-Butyl-1,5-diphenyl-1H-pyrazole;

Chemical Property of 3-BUTYL-1,5-DIPHENYL-1H-PYRAZOLE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 418.797°C at 760 mmHg
• Flash Point: 207.081°C
• PSA: 17.82000
• Density: 1.033g/cm³
• LogP: 4.88190

Purity/Quality:

99% ^*data from raw suppliers

3-BUTYL-1,5-DIPHENYL-1H-PYRAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BUTYL-1,5-DIPHENYL-1H-PYRAZOLE

There total 6 articles about 3-BUTYL-1,5-DIPHENYL-1H-PYRAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

diphenyl diselenide (1666-13-3) + C19H20N2 → 3-butyl-1,5-diphenyl-1H-pyrazole (871110-25-7) + 3-butyl-1,5-diphenyl-4-(phenylselanyl)-1H-pyrazole

Guidance literature:

With potassium peroxymonosulfate sulfate; ethanol; at 70 ℃; for 5h; Green chemistry;

DOI:10.1055/s-0037-1611747

Reference yield: 60.0%

n-butyl magnesium bromide (693-03-8) + 1,5-diphenyl-3-(methylsulfonyl)-1H-pyrazole (871110-24-6) → 3-butyl-1,5-diphenyl-1H-pyrazole (871110-25-7)

Guidance literature:

n-butyl magnesium bromide; With bis(triphenylphosphine)nickel(II) chloride; In diethyl ether; benzene; for 0.25h; Heating;

1,5-diphenyl-3-(methylsulfonyl)-1H-pyrazole; In diethyl ether; benzene; for 12h; Heating;

DOI:10.1021/jo051771u

Reference yield: 38.0%

carbon monoxide (201230-82-2) + phenylhydrazine hydrochloride (59-88-1) + hex-1-yne (693-02-7) → 3-butyl-1,5-diphenyl-1H-pyrazole (871110-25-7)

Guidance literature:

With oxygen; palladium diacetate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; at 100 ℃; for 8h; regioselective reaction; Molecular sieve; Schlenk technique;

DOI:10.1021/acs.orglett.7b01447

upstream raw materials:

n-butyl magnesium bromide

1,5-diphenyl-3-(methylsulfonyl)-1H-pyrazole

methyl 3-oxo-3-phenylpropanedithioate

1,5-diphenyl-3-(methylthio)-1H-pyrazole

Refernces

• 1、 Tu, Yongliang,Zhang, Zhenming,Wang, Tao,Ke, Jiamei,Zhao, Junfeng. "A Regioselective Approach to Trisubstituted Pyrazoles via Palladium-Catalyzed Oxidative Sonogashira-Carbonylation of Arylhydrazines". supporting information. p. 3466 - 3469. Retrieved 2017/07/15.