C₇₉H₁₄₈O₁₃SSi₄

Base Information

• Chemical Name: C₇₉H₁₄₈O₁₃SSi₄
• CAS No.: 423771-98-6
• Molecular Formula: C₇₉H₁₄₈O₁₃SSi₄
• Molecular Weight: 1450.44
• Mol file: 423771-98-6.mol

Synonyms:C₇₉H₁₄₈O₁₃SSi₄

Chemical Property of C₇₉H₁₄₈O₁₃SSi₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₇₉H₁₄₈O₁₃SSi₄

There total 13 articles about C₇₉H₁₄₈O₁₃SSi₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

triethylsilyl chloride (994-30-9) + N-benzoyladenine (4005-49-6) → C79H148O13SSi4 (423771-98-6)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 23 ℃;

DOI:10.1016/S0960-894X(96)00620-8

Reference yield:

9-(tert-butyl-dimethyl-silanyloxy)-29-(3,4-dimethoxy-benzyloxymethoxy)-23,25-dihydroxy-13,19-dimethoxy-30-(5-methoxy-3-methyl-tetrahydro-furan-2-yl)-8,10,17,24,26-pentamethyl-7-methylsulfanylmethoxy-hentriaconta-2,4,14,20-tetraenoic acid ethyl ester (423771-83-9) → C79H148O13SSi4 (423771-98-6)

Guidance literature:

Multi-step reaction with 7 steps

1: 99 percent / LiOH / methanol; H₂O / 13.5 h / 20 °C

2: 35 percent / Et₃N; DMAP; 2,4,6-trichlorobenzoyl chloride / CH₂Cl₂ / 2.5 h / 20 °C

3: 85 percent / imidazole / dimethylformamide / 16 h / 60 °C

4: 1,2-dimethoxy-ethane; H₂O / 6.5 h / 20 °C

5: 67 percent / sodium trimethoxyborohydride / methanol / 4.5 h / 20 °C

6: 100 percent / Et₃N; DMAP / CH₂Cl₂ / 0.58 h / 20 °C

7: 100 percent / imidazole / dimethylformamide / 3 h / 20 °C

With 1H-imidazole; dmap; lithium hydroxide; 2,4,6-trichlorobenzoyl chloride; sodium trimethoxyborohydride; triethylamine; In methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)01206-6

Reference yield:

9-(tert-butyl-dimethyl-silanyloxy)-29-(3,4-dimethoxy-benzyloxymethoxy)-23,25-dihydroxy-13,19-dimethoxy-30-(5-methoxy-3-methyl-tetrahydro-furan-2-yl)-8,10,17,24,26-pentamethyl-7-methylsulfanylmethoxy-hentriaconta-2,4,14,20-tetraenoic acid (423771-84-0) → C79H148O13SSi4 (423771-98-6)

Guidance literature:

Multi-step reaction with 6 steps

1: 35 percent / Et₃N; DMAP; 2,4,6-trichlorobenzoyl chloride / CH₂Cl₂ / 2.5 h / 20 °C

2: 85 percent / imidazole / dimethylformamide / 16 h / 60 °C

3: 1,2-dimethoxy-ethane; H₂O / 6.5 h / 20 °C

4: 67 percent / sodium trimethoxyborohydride / methanol / 4.5 h / 20 °C

5: 100 percent / Et₃N; DMAP / CH₂Cl₂ / 0.58 h / 20 °C

6: 100 percent / imidazole / dimethylformamide / 3 h / 20 °C

With 1H-imidazole; dmap; 2,4,6-trichlorobenzoyl chloride; sodium trimethoxyborohydride; triethylamine; In methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)01206-6

upstream raw materials:

triethylsilyl chloride

N-benzoyladenine

tert-butyldimethylsilyl chloride

10-(tert-butyl-dimethyl-silanyloxy)-24-[6-(3,4-dimethoxy-benzyloxymethoxy)-2-hydroxy-7-(5-methoxy-3-methyl-tetrahydro-furan-2-yl)-1,3-dimethyl-octyl]-14,20-dimethoxy-9,11,18-trimethyl-8-methylsulfanylmethoxy-oxacyclotetracosa-3,5,15,21-tetraen-2-one

Downstream raw materials:

C₇₇H₁₄₄O₁₃Si₄

Refernces

• 1、 Kigoshi, Hideo,Suenaga, Kiyotake,Takagi, Masaki,Akao, Atsushi,Kanematsu, Kengo,Kamei, Noriyuki,Okugawa, Youko,Yamada, Kiyoyuki. "Cytotoxicity and actin-depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and its analogs". . p. 1075 - 1102. Retrieved 2007/10/03.