Technology Process of [(1R,2R)-cis-(2-quinolin-2-yl)cyclohexan-1-oxy]diphenyl phosphine
There total 5 articles about [(1R,2R)-cis-(2-quinolin-2-yl)cyclohexan-1-oxy]diphenyl phosphine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triethylamine; 4,5-dichloroimidazole;
In
1,2-dichloro-ethane;
at 0 ℃;
for 6h;
Reflux;
DOI:10.3987/COM-20-14284
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triphenylphosphine; diethylazodicarboxylate / benzene / 0 - 20 °C / Inert atmosphere
2: methanol; potassium carbonate / 3 h / Reflux
3: triethylamine; 4,5-dichloroimidazole / dichloromethane / 6 h / Reflux
With
methanol; potassium carbonate; triethylamine; 4,5-dichloroimidazole; triphenylphosphine; diethylazodicarboxylate;
In
dichloromethane; benzene;
1: Mitsunobu reaction;
DOI:10.3184/174751911X13082269792294
- Guidance literature:
-
Multi-step reaction with 5 steps
1: aluminum isopropoxide / isopropyl alcohol; toluene / 50 °C / Inert atmosphere
2: (S)-Mandelic acid / ethyl acetate / 0 - 20 °C / Resolution of racemate
3: triphenylphosphine; diethylazodicarboxylate / toluene / 16 h / 20 °C / Inert atmosphere
4: potassium carbonate / methanol / 1.5 h / Reflux; Inert atmosphere
5: 4,5-dichloroimidazole; triethylamine / 1,2-dichloro-ethane / 6 h / 0 °C / Reflux
With
(S)-Mandelic acid; aluminum isopropoxide; potassium carbonate; triethylamine; 4,5-dichloroimidazole; triphenylphosphine; diethylazodicarboxylate;
In
methanol; ethyl acetate; 1,2-dichloro-ethane; isopropyl alcohol; toluene;
3: |Mitsunobu Displacement;
DOI:10.3987/COM-20-14284