α-Tosylamino-β-methyl-valerylchlorid

Base Information

• Chemical Name: α-Tosylamino-β-methyl-valerylchlorid
• CAS No.: 72676-80-3
• Molecular Formula: C₁₃H₁₈ClNO₃S
• Molecular Weight: 303.81
• Mol file: 72676-80-3.mol

Synonyms:α-Tosylamino-β-methyl-valerylchlorid

Chemical Property of α-Tosylamino-β-methyl-valerylchlorid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-Tosylamino-β-methyl-valerylchlorid

There total 6 articles about α-Tosylamino-β-methyl-valerylchlorid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methyl-2-(4-methylphenylsulfonamido)pentanoic acid (34235-81-9) → α-Tosylamino-β-methyl-valerylchlorid (72676-80-3)

Guidance literature:

With thionyl chloride; In benzene; at 20 ℃; for 3.33333h; Reflux;

DOI:10.1080/07391102.2021.1893818

Reference yield:

3-methyl-2-{[(4-methylphenyl)sulfonyl]amino}pentanoic acid (34235-81-9) → N-(toluene-4-sulfonyl)-L-isoleucyl chloride (72676-80-3)

Guidance literature:

With thionyl chloride; In benzene; at 60 ℃; for 3h;

DOI:10.1021/jo034275j

Reference yield:

L-isoleucine (73-32-5,959215-79-3,18875-42-8) → N-(toluene-4-sulfonyl)-L-isoleucyl chloride (72676-80-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / NaOH / H₂O / 6 h / 60 °C

2: thionyl chloride / benzene / 3 h / 60 °C

With sodium hydroxide; thionyl chloride; In water; benzene;

DOI:10.1021/jo034275j

upstream raw materials:

p-toluenesulfonyl chloride

isoleucine

3-methyl-2-(4-methylphenylsulfonamido)pentanoic acid

3-methyl-2-{[(4-methylphenyl)sulfonyl]amino}pentanoic acid

Downstream raw materials:

β-(DL-N-Tosylisoleucylamino)-propionamid

N-[(1S,2S)-1-(2-Chloro-acetyl)-2-methyl-butyl]-4-methyl-benzenesulfonamide

N-[(1R,2R)-1-(2-Diazo-acetyl)-2-methyl-butyl]-4-methyl-benzenesulfonamide

β-(DL-N-Tosylisoleucylamino)-propionitril

Refernces

• 1、 Devi, Kirna,Awasthi, Pamita. "Isoleucine with secondary sulfonamide functionality as anticancer, antibacterial and antifungal agents". . . Retrieved 2021/03/18.