1,2-Dimethyl-1H-indole-3-carboxaldehyde

Base Information

• Chemical Name: 1,2-Dimethyl-1H-indole-3-carboxaldehyde
• CAS No.: 38292-40-9
• Molecular Formula: C11H11NO
• Molecular Weight: 173.214
• Hs Code.: 2933990090
• Mol file: 38292-40-9.mol

Synonyms:Indole-3-carboxaldehyde,1,2-dimethyl- (6CI);1,2-Dimethyl-3-formylindole;1,2-Dimethylindole-3-carboxaldehyde;3-Formyl-1,2-dimethylindole;

Chemical Property of 1,2-Dimethyl-1H-indole-3-carboxaldehyde

Chemical Property:

• Vapor Pressure: 0.000131mmHg at 25°C
• Melting Point: 127-129
• Refractive Index: 1.575
• Boiling Point: 334.097 °C at 760 mmHg
• Flash Point: 155.857 °C
• PSA: 22.00000
• Density: 1.09 g/cm³
• LogP: 2.29920

Purity/Quality:

99% ^*data from raw suppliers

1,2-Dimethyl-1H-indole-3-carboxaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2-Dimethyl-1H-indole-3-carboxaldehyde

There total 18 articles about 1,2-Dimethyl-1H-indole-3-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

→ 1,2-dimethyl-1H-indole-3-carbaldehyde (38292-40-9)

Guidance literature:

Reference yield: 95.0%

1,2-dimethylindole (875-79-6) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 1,2-dimethyl-1H-indole-3-carbaldehyde (38292-40-9)

Guidance literature:

N,N-dimethyl-formamide; With oxalyl dichloride; at 0 ℃; for 1h;

1,2-dimethylindole; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

With sodium hydroxide; In N,N-dimethyl-formamide; at 100 ℃; for 0.166667h;

DOI:10.1016/j.ejmech.2013.04.057

Reference yield: 90.0%

1,2-dimethylindole (875-79-6) + Glyoxilic acid (298-12-4) → 1,2-dimethyl-1H-indole-3-carbaldehyde (38292-40-9)

Guidance literature:

With sodium perchlorate; dimethyl amine; In dimethyl sulfoxide; at 20 ℃; for 7h; Electrochemical reaction;

DOI:10.1021/acs.orglett.9b01971

upstream raw materials:

1,2-dimethylindole

N-methyl-N-phenylformamide

2-methyl-1H-indole-3-carbaldehyde

dimethyl sulfate

Downstream raw materials:

5-(1,2-dimethylindol-3-ylmethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione

2-Benzhydrylidene-3-[1-(1,2-dimethyl-1H-indol-3-yl)-meth-(E)-ylidene]-succinic acid 4-ethyl ester

2-Cyclohexylidene-3-[1-(1,2-dimethyl-1H-indol-3-yl)-meth-(E)-ylidene]-succinic acid 4-ethyl ester

2-(1,2-Dimethyl-1H-indol-3-yl)-5,7-dimethyl-1,3-diaza-tricyclo[3.3.1.1^3,7]decan-6-one

Refernces

• 1、 Ming, Yong-Chao,Lv, Xue-Jiao,Liu, Ming,Liu, Yan-Kai. "Synthesis of Chiral Polycyclic Tetrahydrocarbazoles by Enantioselective Aminocatalytic Double Activation of 2-Hydroxycinnamaldehydes with Dienals". supporting information. p. 6515 - 6519. Retrieved 2021/09/02.
• 2、 Chen, Xiong,Feng, Xiao,Han, Songjie,Li, Chunzhi,Li, He,Li, Ziping,Liu, Xiaoming,Shao, Pengpeng,Xia, Hong. "Screening metal-free photocatalysts from isomorphic covalent organic frameworks for the C-3 functionalization of indoles". supporting information. p. 8706 - 8715. Retrieved 2020/05/16.