5'-diphenylphosphate-5'-deoxy-2',3'-isopropylidene adenosine

Base Information

• Chemical Name: 5'-diphenylphosphate-5'-deoxy-2',3'-isopropylidene adenosine
• CAS No.: 78111-39-4
• Molecular Formula: C₂₅H₂₆N₅O₇P
• Molecular Weight: 539.484
• Mol file: 78111-39-4.mol

Synonyms:5'-diphenylphosphate-5'-deoxy-2',3'-isopropylidene adenosine

Chemical Property of 5'-diphenylphosphate-5'-deoxy-2',3'-isopropylidene adenosine

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-diphenylphosphate-5'-deoxy-2',3'-isopropylidene adenosine

There total 3 articles about 5'-diphenylphosphate-5'-deoxy-2',3'-isopropylidene adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

diphenyl phosphoryl azide (26386-88-9) + 2',3'-isopropylidene adenosine (362-75-4) → 5'-diphenylphosphate-5'-deoxy-2',3'-isopropylidene adenosine (78111-39-4)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; at 20 ℃; for 3h;

DOI:10.1016/S0040-4039(01)00395-1

Reference yield: 10.0%

2',3'-isopropylidene adenosine (362-75-4) + chlorophosphoric acid diphenyl ester (2524-64-3) → 5'-diphenylphosphate-5'-deoxy-2',3'-isopropylidene adenosine (78111-39-4) + 2',3'-O-isopropylidene-N6-diphenylphosphoryl-adenosine-5'-O-diphenyl phosphate (78111-40-7)

Guidance literature:

With pyridine; for 1h; Ambient temperature;

Reference yield:

diphenyl hydrogen phosphate (838-85-7) + 2',3'-isopropylidene adenosine (362-75-4) → 5'-diphenylphosphate-5'-deoxy-2',3'-isopropylidene adenosine (78111-39-4)

Guidance literature:

With 1H-imidazole; polystyryl diphenyl phosphine-iodine; Yield given. Multistep reaction;

DOI:10.1055/s-1997-950

upstream raw materials:

2',3'-isopropylidene adenosine

chlorophosphoric acid diphenyl ester

diphenyl hydrogen phosphate

diphenyl phosphoryl azide

Downstream raw materials:

5'-amino-5'-deoxy-2',3'-O-isopropylideneadenosine

5'-azido-5'-deoxy-2',3'-O-isopropylidene adenosine

5’-O-diphenylphosphoryl-adenosine

Refernces

• 1、 Caputo, Romualdo,Guaragna, Annalisa,Pedatella, Silvana,Palumbo, Giovanni. "Mild and Regiospecific Phosphorylation of Nucleosides". . p. 917 - 918. Retrieved 1997.
• 2、 Charubala, Ramamurthy,Pfleiderer, Wolfgang. "NUCLEOTIDES, XIII: PHOSPHORYLATIONS OF ADENOSINE AND 2'-DEOXYADENOSINE BY PHOSPHOROCHLORIDATES". . p. 761 - 776. Retrieved 2007/10/02.