Pyridine-2,6-dicarbohydrazide

Base Information

• Chemical Name: Pyridine-2,6-dicarbohydrazide
• CAS No.: 5112-36-7
• Molecular Formula: C7H9N5O2
• Molecular Weight: 195.181
• Hs Code.: 2933399090
• Mol file: 5112-36-7.mol

Synonyms:Pyridine 2,6-dicarboxylic dihydrazide;Pyridine-2,6-dicarboxylic dihydrazide;

Chemical Property of Pyridine-2,6-dicarbohydrazide

Chemical Property:

• Refractive Index: 1.636
• PSA: 123.13000
• Density: 1.417g/cm³
• LogP: 0.47100

Purity/Quality:

98%min ^*data from raw suppliers

Pyridine-2,6-dicarbohydrazide 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyridine-2,6-dicarbohydrazide

There total 6 articles about Pyridine-2,6-dicarbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,6-bis(methoxycarbonyl)pyridine (5453-67-8) → pyridine-2,6-dicarbohydrazide (5112-36-7)

Guidance literature:

With hydrazine hydrate; In ethanol; Heating;

DOI:10.1039/b106907c

Reference yield: 95.0%

2,6-Pyridinedicarbonyl dichloride (3739-94-4) → pyridine-2,6-dicarbohydrazide (5112-36-7)

Guidance literature:

With hydrazine hydrate; In ethanol; Reflux;

DOI:10.3184/174751914X13896291543361

Reference yield: 90.0%

2,6-bis(methoxycarbonyl)pyridine (5453-67-8) → pyridine-2,6-dicarbohydrazide (5112-36-7) + 6-methyloxycarbonyl-2-pyridinecarboxylic acid hydrazide (459409-89-3)

Guidance literature:

With NH₂NH₂ (98percent); In methanol; for 18h; Heating;

DOI:10.1039/b201076n

upstream raw materials:

2,6-bis(methoxycarbonyl)pyridine

diethyl-2,6-pyridinedicarbonyl ester

2,6-Pyridinedicarbonyl dichloride

Pyridine-2,6-dicarboxylic acid

Downstream raw materials:

C₂₃H₁₃Cl₂N₇O₂

bis(o-hydroxyacetophenone)-2,6-dipicolinoyl dihydrazone

ZrO(C₆H₅CNNCOC₅H₃NCONNCCH₂CH₃)(H₂O)2

2,6-bis[4-nitrophenyl(thioureidocarbomoyl)]pyridine

Refernces

• 1、 ?evik, ?zge,?enkarde?, Sevil,Abbak, Mürüvvet,Durak, As?m Tu?rul,Ekrek, Sedanur,Güniz Kü?ükgüzel, ?.,Kü?ükgüzel, ?lkay,Ka?katepe, Banu,Türe, Asl?. "Novel 2,6-disubstituted pyridine hydrazones: Synthesis, anticancer activity, docking studies and effects on caspase-3-mediated apoptosis". . . Retrieved 2021.
• 2、 Duke, Rebecca M.,O'Brien, John E.,McCabe, Thomas,Gunnlaugsson, Thorfinnur. "Colorimetric sensing of anions in aqueous solution using a charge neutral, cleft-like, amidothiourea receptor: Tilting the balance between hydrogen bonding and deprotonation in anion recognition". . p. 4089 - 4092. Retrieved 2008.
• 3、 Taha, Ziyad A.,Ababneh, Taher S.,Hijazi, Ahmed K.,Abu-Salem, Qutaiba,Ajlouni, Abdulaziz M.,Ebwany, Shroq. "Synthesis, density functional theory calculations and luminescence of lanthanide complexes with 2,6-bis[(3-methoxybenzylidene)hydrazinocarbonyl] pyridine Schiff base ligand". . p. 79 - 88. Retrieved 2018.
• 4、 Duke, Rebecca M.,Gunnlaugsson, Thorfinnur. "Fluorescent sensing of anions using a bis-quinoxaline amidothiourea based supramolecular cleft; an example of an anion-induced deprotonation event". . p. 5402 - 5405. Retrieved 2010.
• 5、 Manna, Saikat Kumar,Mondal, Debasish,Mukhopadhyay, Subrata,Pal, Kunal,Pathak, Sudipta,Pramanik, Samit. "Chromogenic and fluorogenic "off-on-off" chemosensor for selective and sensitive detection of aluminum (Al3+) and bifluoride (HF2-) ions in solution and in living Hep G2 cells: Synthesis, experimental and theoretical studies". . p. 13259 - 13265. Retrieved 2020/10/07.