DL-4-Amino-2-fluorobutyric acid

Base Information

• Chemical Name: DL-4-Amino-2-fluorobutyric acid
• CAS No.: 34069-57-3
• Molecular Formula: C₄H₈FNO₂
• Molecular Weight: 121.111
• Mol file: 34069-57-3.mol

Synonyms:Butanoic acid, 4-amino-2-fluoro-;

Chemical Property of DL-4-Amino-2-fluorobutyric acid

Chemical Property:

• Melting Point: 197-198 °C
• Boiling Point: 253.7 °C at 760 mmHg
• Flash Point: 107.2 °C
• PSA: 63.32000
• Density: 1.227 g/cm³
• LogP: 0.45820

Purity/Quality:

96% 1H NMR ^*data from raw suppliers

DL-4-AMINO-2-FLUOROBUTYRIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DL-4-Amino-2-fluorobutyric acid

There total 9 articles about DL-4-Amino-2-fluorobutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

D,L-erythro,threo-4-fluoroglutamic acid (2708-77-2,149117-03-3,91383-48-1,91383-47-0) → (+/-)-2-Fluoro-4-aminobutanoic acid (5130-17-6,34069-57-3) + (-)-D-erythro-4-fluoroglutamic acid (132746-47-5,149117-03-3,91383-48-1,91383-47-0) + d-threo-(2R,4R)-4-Fluoroglutamic acid (149117-03-3,91383-48-1,91383-47-0)

Guidance literature:

With sodium hydroxide; glutamic decarboxylase ex Escherichia coli; pyridoxal 5'-phosphate; In pyridine; water; at 30 ℃; for 48h;

DOI:10.1016/S0022-1139(99)00188-8

Reference yield: 83.0%

(+/-)-threo-4-Fluoroglutamic acid (149117-03-3,91383-48-1,91383-47-0) → d-threo-(2R,4R)-4-Fluoroglutamic acid (149117-03-3,91383-48-1,91383-47-0) + (S)-4-Amino-2-fluorobutyric acid (34069-57-3)

Guidance literature:

With sodium hydroxide; glutamic decarboxylase ex Escherichia coli; pyridoxal 5'-phosphate; In pyridine; water; at 30 ℃; for 24h;

DOI:10.1016/S0022-1139(99)00188-8

Reference yield: 75.0%

(+/-)-erythro-4-Fluoroglutamic acid (149117-03-3,91383-48-1,91383-47-0) → (-)-D-erythro-4-fluoroglutamic acid (132746-47-5,149117-03-3,91383-48-1,91383-47-0) + (R)-4-Amino-2-fluorobutyric acid (34069-57-3)

Guidance literature:

With sodium hydroxide; glutamic decarboxylase ex Escherichia coli; pyridoxal 5'-phosphate; In pyridine; water; at 30 ℃; for 24h;

DOI:10.1016/S0022-1139(99)00188-8

upstream raw materials:

2-fluoro-4-phthalimido-butyric acid

2-Fluor-2-<2-(4-nitro-benzoylamino)-aethyl>-malonsaeure-diaethylester

D,L-erythro,threo-4-fluoroglutamic acid

(2S,4S)-L-threo-4-fluoroglutamic acid

Refernces

• 1、 Bory, Sonia,Dubois, Joelle,Gaudry, Michel,Marquet, Andree,Lacombe, Liliane,Weinstein, Shulamith. "Resolution of γ-Methyl and γ-Fluoroglutamic Acids. Lack of Stereospecificity of Leucine Aminopeptidase with L-Leucyl-L-erythro-γ-substituted Glutamates". . p. 475 - 480. Retrieved 2007/10/02.