Uridine 5'-diphosphogalactose disodium salt

Base Information

• Chemical Name: Uridine 5'-diphosphogalactose disodium salt
• CAS No.: 137868-52-1
• Molecular Formula: C₁₅H₂₂N₂O₁₇P₂*2Na
• Molecular Weight: 610.27
• Hs Code.: 29400090
• DSSTox Substance ID: DTXSID901036029
• Mol file: 137868-52-1.mol

Synonyms:Uridine 5'-diphosphogalactose disodium salt;DTXSID901036029;Uridine 5'-diphosphogalactose disodium salt, >=97.0%;Uridine 5'-diphosphogalactose disodium salt, >=98.0% (HPLC)

Chemical Property of Uridine 5'-diphosphogalactose disodium salt

Chemical Property:

• Flash Point: 27 °C
• PSA: 322.27000
• LogP: -3.91730
• Storage Temp.: −20°C
• Solubility.: H2O: 50 mg/mL, clear, colorless
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 17
• Rotatable Bond Count: 9
• Exact Mass: 610.01890980
• Heavy Atom Count: 38
• Complexity: 948

Purity/Quality:

98%,99%, ^*data from raw suppliers

UDP-D-galactosedisodiumsalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): 5374254
• Hazard Codes: Xi,R
• Statements: 36/37/38-10
• Safety Statements: 26-16

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)([O-])OP(=O)([O-])OC3C(C(C(C(O3)CO)O)O)O)O)O.[Na+].[Na+]
• Isomeric SMILES: C1=CN(C(=O)NC1=O)C2[C@@H]([C@@H]([C@H](O2)COP(=O)([O-])OP(=O)([O-])OC3[C@@H]([C@H]([C@H]([C@H](O3)CO)O)O)O)O)O.[Na+].[Na+]
• Description: Udp-alpha-d-galactose disodium salt is an endogenous nucleotide sugar. The compound is a donor substrate for galactosyltransferases employed in the biosynthesis of galactose-containing oligosaccharides.
• Uses: Gal transferase substrate UDP-D-galactose disodium salt is a uridine (U829910) derivative used in the synthesis of 5-CF3 UDP non-natural sugar nucleotides which are micromolar inhibitors of galactosyltransferases.

Technology Process of Uridine 5'-diphosphogalactose disodium salt

There total 1 articles about Uridine 5'-diphosphogalactose disodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

galactose-α-1-phosphate barium salt (14795-21-2,38987-77-8,51306-18-4,71662-16-3,103213-39-4,120612-21-7,121376-40-7) + uridine 5'-triphosphate trisodium salt (1476-50-2,14264-46-1,19817-92-6,36051-69-1,74674-72-9) → uridine-5'-diphosphogalactose disodium salt (6858-46-4,7333-33-7,14656-80-5,28053-08-9,53829-41-7,108320-88-3,137868-52-1,2956-16-3)

Guidance literature:

With uridine 5'-diphosphoglucose disodium salt; galactose-1-phosphate uridyltransferase, UDP-glucose pyrophosphorylase, pyrophosphatase, pH 8.5;

DOI:10.1021/jo00027a029

Reference yield: 99.0%

12-[N-(5-oxohexanoyl)-l-phenylalanyl-l-glutamyl-l-phenylalanyl-glycinyl]-aminododecyl 2-acetamido-2-deoxy-β-d-glucopyranoside (1036637-19-0) + uridine-5'-diphosphogalactose disodium salt (6858-46-4,7333-33-7,14656-80-5,28053-08-9,53829-41-7,108320-88-3,137868-52-1,2956-16-3) → 12-[N-(5-oxohexanoyl)-l-phenylalanyl-l-glutamyl-l-phenylalanyl-glycinyl]-aminododecyl O-(β-d-galactopyranosyl)-(1→4)-2-acetamido-2-deoxy-β-d-glucopyranoside (1036637-21-4)

Guidance literature:

With β1,4-galactosyltransferase; cyclomaltooctaose; manganese(ll) chloride; In water; at 25 ℃; pH=7.0;

DOI:10.1016/j.tetlet.2008.03.103

Reference yield: 82.0%

C30H40N4O15 + uridine-5'-diphosphogalactose disodium salt (6858-46-4,7333-33-7,14656-80-5,28053-08-9,53829-41-7,108320-88-3,137868-52-1,2956-16-3) → C36H50N4O20

Guidance literature:

With β-1,4-galactosyltransferase (LgtB); manganese(ll) chloride; In aq. buffer; at 37 ℃; for 3h; Enzymatic reaction;

DOI:10.1021/acs.jmedchem.9b00303

upstream raw materials:

galactose-α-1-phosphate barium salt

uridine 5'-triphosphate trisodium salt

Downstream raw materials:

(5-acetamido-3,5-dideoxy-α-D-glycero-D-galacto-2-nonulopyranulosonic acid)-(2,6)-β-D-galactopyranosyl-(1,4)-2-acetamido-2-deoxyglucopyranose

N⁴-<(5-acetamido-3,5-dideoxy-α-D-glycero-D-galacto-2-nonulopyranulosonic acid)-(2,6)-β-D-galactopyranosyl-(1,4)-2-acetamido-2-deoxy-β-D-glucopyranosyl>-N²-<(allyloxy)carbonyl-L-phenylalanyl>-L-asparaginyl-L-seryl-L-threonyl-L-isoleucine

[1-¹³C₁]-β-D-fructofuranosyl α-D-glucopyranoside

uridine-5'-diphosphate-2-deoxy-2-fluorogalactose

Refernces