METHYL 3-BROMO-4-METHOXYBENZOATE 98

Base Information

• Chemical Name: METHYL 3-BROMO-4-METHOXYBENZOATE 98
• CAS No.: 35450-37-4
• Molecular Formula: C9H9BrO3
• Molecular Weight: 245.073
• Hs Code.: 2918990090
• Mol file: 35450-37-4.mol

Synonyms:p-Anisicacid, 3-bromo-, methyl ester (6CI);3-Bromo-4-methoxybenzoic acid methyl ester;Methyl 3-bromo-4-methoxybenzoate;Methyl 3-bromoanisate;

Chemical Property of METHYL 3-BROMO-4-METHOXYBENZOATE 98

Chemical Property:

• Vapor Pressure: 0.00129mmHg at 25°C
• Melting Point: 98-100 °C(lit.)
• Refractive Index: 1.537
• Boiling Point: 298.1 °C at 760 mmHg
• Flash Point: 134.1 °C
• PSA: 35.53000
• Density: 1.463 g/cm³
• LogP: 2.24430
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Toluene

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl 3-Bromo-4-methoxybenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 3-BROMO-4-METHOXYBENZOATE 98

There total 18 articles about METHYL 3-BROMO-4-METHOXYBENZOATE 98 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 4-methoxybenzoate (121-98-2) → methyl 3-bromo-4-methoxybenzoate (35450-37-4)

Guidance literature:

With N-Bromosuccinimide; diphenyldisulfane; In acetonitrile; at 20 ℃; for 12h; Reagent/catalyst;

DOI:10.1021/acs.joc.9b00817

Reference yield: 100.0%

methanol (67-56-1) + 3-bromo-4-methoxybenzoic acid (99-58-1) → methyl 3-bromo-4-methoxybenzoate (35450-37-4)

Guidance literature:

With sulfuric acid; for 24h; Reflux;

DOI:10.1016/j.ejmech.2015.11.012

Reference yield: 93.0%

3-bromo-4-methoxybenzoic acid (99-58-1) + methyl iodide (74-88-4) → methyl 3-bromo-4-methoxybenzoate (35450-37-4)

Guidance literature:

With caesium carbonate; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 21h;

upstream raw materials:

diazomethane

methyl 3-bromo-4-hydroxybenzoate

methanol

3-bromo-4-methoxybenzoic acid

Downstream raw materials:

3-Allyl-4-methoxy-benzoic acid methyl ester

3-Ethyl-4-methoxybenzoesaeure-methylester

(3-bromo-4-methoxy-phenyl)-methanol

2-bromo-4-(bromomethyl)-1-methoxybenzene

Refernces

• 1、 Bhardwaj, Nivedita,Goel, Bharat,Indra, Arindam,Jain, Shreyans K.,Singh, Ajit Kumar,Tripathi, Nancy. "Ni-NiO heterojunctions: a versatile nanocatalyst for regioselective halogenation and oxidative esterification of aromatics". . p. 14177 - 14183. Retrieved 2021/08/16.
• 2、 Arrieta, Ana,Cossío, Fernando P.,Granados, Albert,Shafir, Alexandr,Vallribera, Adelina. "Stepwise mechanism for the bromination of arenes by a hypervalent iodine reagent". . p. 2142 - 2150. Retrieved 2020/03/11.