IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID

Base Information

• Chemical Name: IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID
• CAS No.: 133427-08-4
• Molecular Formula: C8H6N2O2
• Molecular Weight: 162.15
• Hs Code.: 2933990090
• Mol file: 133427-08-4.mol

Synonyms:IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID;H-imidazo[1,2-a]pyridine-8-carboxylic acid;Imidazo[1,2-a]pyridine-8-...;IMidazo[1,2-a]pyridin-8-carboxylic acid;H-iMidazo[1,2-a]pyridine-8-carbo×ylic acid

Chemical Property of IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID

Chemical Property:

• Refractive Index: 1.676
• PKA: -0.61±0.41(Predicted)
• PSA: 54.60000
• Density: 1.418 g/cm³
• LogP: 1.03250
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

Imidazo[1,2-a]pyridine-8-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID

There total 4 articles about IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 8-imidazo<1,2-a>pyridinecarboxylate (133427-07-3) → H-imidazo[1,2-α]pyridine-8-carboxylic acid (133427-08-4)

Guidance literature:

methyl 8-imidazo<1,2-a>pyridinecarboxylate; With lithium hydroxide; water; In methanol; at 20 ℃; for 1.5h;

With hydrogenchloride; In water;

Reference yield:

2-chloroethanal (107-20-0) + 2-aminopyridin-3-carboxylic acid (5345-47-1) → H-imidazo[1,2-α]pyridine-8-carboxylic acid (133427-08-4)

Guidance literature:

In ethanol; water; Heating;

DOI:10.1021/jm0509501

Reference yield:

2-aminopyridin-3-carboxylic acid (5345-47-1) + 1-bromo-2,2-dimethoxyethane (7252-83-7) → H-imidazo[1,2-α]pyridine-8-carboxylic acid (133427-08-4)

Guidance literature:

In acetonitrile; at 150 ℃; for 2h; Product distribution / selectivity; microwave irradiation;

upstream raw materials:

2-chloroethanal

2-aminopyridin-3-carboxylic acid

methyl 8-imidazo<1,2-a>pyridinecarboxylate

Bromoacetaldehyde diethyl acetal

Downstream raw materials:

3-bromoimidazo[1,2-a]pyridine-8-carboxylic acid

(4-(2,4-difluorophenethyl)piperazin-1-yl)(imidazo[l,2-α]pyridin-8-yl)methanone

methyl 8-imidazo<1,2-a>pyridinecarboxylate

3-(4-fluorophenyl)-imidazo[1,2-a]pyridine-8-carboxylic acid

Refernces

• 1、 -. "HETEROCYCLIC COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS". Page/Page column 46. . Retrieved 2011/06/11.
• 2、 Becker, Daniel P.,Flynn, Daniel L.,Moormann, Alan E.,Nosal, Roger,Villamil, Clara I.,Loeffler, Richard,Gullikson, Gary W.,Moummi, Chafiq,Yang, Dai-C.. "Pyrrolizidine esters and amides as 5-HT4 receptor agonists and antagonists". . p. 1125 - 1139. Retrieved 2007/10/03.