1H,1H-Perfluorohexan-1-ol

Base Information

• Chemical Name: 1H,1H-Perfluorohexan-1-ol
• CAS No.: 423-46-1
• Molecular Formula: C6H3F11O
• Molecular Weight: 300.072
• Hs Code.: 29055900
• European Community (EC) Number: 691-551-1
• DSSTox Substance ID: DTXSID00382070
• Nikkaji Number: J3.557.042J
• Wikidata: Q81977559
• Mol file: 423-46-1.mol

Synonyms:(nonadecafluorononyl)methanol;1,1,2,2-tetrahydroperfluoro dodecanol;1,1,2,2-tetrahydroperfluoro-1-dodecanol;1,1,2,2-tetrahydroperfluorodecanol;1-dodecanol, 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-tricosafluoro;1-dodecanol, 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-heneicosafluoro-;1-octanol, 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-;10-1 fluorotelomer alcohol;10-1 FTOH;10-2 fluorotelomer alcohol;10-2 FTOH;10:1 fluorotelomer alcohol;10:1 FTOH;10:2 fluorotelomer alcohol;10:2 FTOH;11-1 fluorotelomer alcohol;11-1 FTOH;11:1 fluorotelomer alcohol;11:1 FTOH;1122-FTOH cpd;1h,1h,2h,2h-perfluoro-1-decanol;1H,1H,2H,2H-perfluoro-1-dodecanol;1H,1H,2H,2H-perfluorodecanol;1H,1H,2H,2H-perfluorododecan-1-ol;1H,1H,2H,2H-perfluorooctan-1-ol;1H,1H-nonadecafluoro-1-decanol;1H,1H-perfluoro-1-dodecanol;1H,1H-perfluoro-1-nonanol;1H,1H-perfluoro-1-undecanol;1H,1H-perfluoroheptan-1-ol;1H,1H-perfluorohexan-1-ol;1H,1H-perfluoroundecan-1-ol;1H,1H-undecafluoro-1-hexanol;2,2,3,3,4,4,5,5,6,6,6-undecafluorohexan-1-ol;2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptan-1-ol;2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-nonadecafluoro-1-decanol;2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-nonadecafluorodecan-1-ol;2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heneicosafluoro-1-undecanol;2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-henicosafluoroundecan-1-ol;2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-henicosakis(fluoranyl)undecan-1-ol;2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-tricosafluoro-1-dodecanol;2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-tricosafluorododecan-1-ol;2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-heptadecafluoro-1-nonanol;2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-heptadecafluorononan-1-ol;2-(perfluorohexyl)ethanol;2-(perfluorohexyl)ethyl alcohol;2-perfluorohexylethanol;2-perfluorooctylethanol;3,3,4,4,5,5,6,6,6-nonafluorohexan-1-ol;3,3,4,4,5,5,6,6,6-nonafluorohexanol;3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-1-octanol;3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctan-1-ol;3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctanol;3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-Henicosafluorododecan-1-ol;3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-henicosafluorododecanol;3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10-heptadecafluorodecanol;3-ethyl-4,5-dihydroisoxazole-5-carboxylic acid;4-(nonafluorobutyl)-1-butanol;4-2 fluorotelomer alcohol;4-2 FTOH;4-4 fluorotelomer alcohol;4-4 FTOH;4:2 fluorotelomer alcohol;4:2 FTOH;4:4 fluorotelomer alcohol;4:4 FTOH;5,5,6,6,7,7,8,8,8-nonafluorooctan-1-ol;5-1 fluorotelomer alcohol;5:1 fluorotelomer alcohol;5:1 FTOH;6-1 fluorotelomer alcohol;6-1 FTOH;6-2 fluorotelomer alcohol;6:1 fluorotelomer alcohol;6:1 FTOH;6:2 fluorotelomer alcohol;6:2 FTOH;8-1 fluorotelomer alcohol;8-1 FTOH;8-2 fluorotelomer alcohol;8-2 FTOH;8:1 fluorotelomer alcohol;8:1 FTOH;8:2 fluorotelomer alcohol;8:2 FTOH;9-1 fluorotelomer alcohol;9-1 FTOH;9:1 fluorotelomer alcohol;9:1 FTOH;butyryltrihexylcitrate;fluorotelomer alcohol;fluorotelomer alcohols;FtOH 6:2 fluorotelomer alcohol 6:2;FTOH fluorotelomer alcohol;henicosafluorodecylmethanol;heptadecafluorooctylmethanol

Chemical Property of 1H,1H-Perfluorohexan-1-ol

Chemical Property:

• Vapor Pressure: 8.51mmHg at 25°C
• Refractive Index: 1.284
• Boiling Point: 117.7 °C at 760 mmHg
• PKA: 12.73±0.10(Predicted)
• Flash Point: 25 °C
• PSA: 20.23000
• Density: 1.619 g/cm³
• LogP: 3.08220
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 12
• Rotatable Bond Count: 4
• Exact Mass: 300.00082450
• Heavy Atom Count: 18
• Complexity: 303

Purity/Quality:

98%,99%, ^*data from raw suppliers

1H,1H-Undecafluoro-1-hexanol >96.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 23-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)O
• Uses: 1H,1H-Perfluorohexan-1-ol is a reagent in the synthesis of environmentally safer fluoroalkyl ether synthons.

Technology Process of 1H,1H-Perfluorohexan-1-ol

There total 4 articles about 1H,1H-Perfluorohexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

isopropyl 2,2,3,3,4,4,5,5,6,6,6-undecafluorohexanoate → perfluorohexanol (423-46-1)

Guidance literature:

With RuCl2(DPPEA)(±DAIPEN); hydrogen; sodium methylate; In isopropyl alcohol; at 120 ℃; for 60h; under 750.075 - 30003 Torr; Autoclave;

Reference yield: 86.0%

perfluorohexanoic acid methyl ester (424-18-0) → perfluorohexanol (423-46-1)

Guidance literature:

With carbonylchlorohydrido[bis(2-diphenylphosphinoethyl)amino]ruthenium(II); hydrogen; sodium methylate; In methanol; at 60 ℃; for 23h; under 7500.75 Torr; Temperature; Autoclave;

DOI:10.1039/c3ra43410a

Reference yield:

undecafluorohexanoic acid (307-24-4) → perfluorohexanol (423-46-1)

Guidance literature:

With lithium aluminium tetrahydride;

DOI:10.1016/S0022-1139(96)03490-2

upstream raw materials:

undecafluorohexanoic acid

perfluorohexanoic acid methyl ester

Downstream raw materials:

3-methyl-glutaric acid bis-(1H,1H-undecafluoro-hexyl ester)

2,2,3,3,4,4,5,5,6,6,6-undecafluorohexyl trifluoromethanesulfonate

6-(2-chloromethyl-allyloxy)-1,1,1,2,2,3,3,4,4,5,5-undecafluoro-hexane

2-bromomethyl-acrylic acid 2,2,3,3,4,4,5,5,6,6,6-undecafluoro-hexyl ester

Refernces

• 1、 Lazzari, Dario,Cassani, Maria Cristina,Bertola, Maurizio,Moreno, Francisco Casado,Torrente, Damiano. "Homogeneous catalytic hydrogenation of perfluoro methyl esters". . p. 15582 - 15584. Retrieved 2013/09/12.