isobutyl N-phenethylcarbamate

Base Information

• Chemical Name: isobutyl N-phenethylcarbamate
• CAS No.: 208341-61-1
• Molecular Formula: C₁₃H₁₉NO₂
• Molecular Weight: 221.299
• Mol file: 208341-61-1.mol

Synonyms:isobutyl N-phenethylcarbamate

Chemical Property of isobutyl N-phenethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of isobutyl N-phenethylcarbamate

There total 4 articles about isobutyl N-phenethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

phenethylamine (64-04-0) + isobutyl chloroformate (543-27-1) → isobutyl N-phenethylcarbamate (208341-61-1)

Guidance literature:

With zinc; In benzene; for 0.15h; Ambient temperature;

DOI:10.1016/S0040-4039(98)00464-X

Reference yield:

C14H19NO3 → isobutyl N-phenethylcarbamate (208341-61-1)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: tetrabutylammonium perchlorate / 50 °C / Electrochemical reaction; Sealed tube; Inert atmosphere

With tetrabutylammonium perchlorate; trifluoroacetic acid; In dichloromethane;

DOI:10.1039/d0cc05069e

Reference yield:

phenethylamine (64-04-0) → isobutyl N-phenethylcarbamate (208341-61-1)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 20 °C

3: tetrabutylammonium perchlorate / 50 °C / Electrochemical reaction; Sealed tube; Inert atmosphere

With tetrabutylammonium perchlorate; triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1039/d0cc05069e

upstream raw materials:

phenethylamine

isobutyl chloroformate

Downstream raw materials:

phenethyl isocyanate

Refernces

• 1、 Yadav,Reddy, Gondi Sudershan,Reddy, M. Muralidhar,Meshram. "Zinc promoted simple and convenient synthesis of carbamates: An easy access for amino group protection". . p. 3259 - 3262. Retrieved 2007/10/03.
• 2、 Bernasconi, S.,Comini, A.,Corbella, A.,Gariboldi, P.,Sisti, M.. "Activation of 2-Alkenoic Acids as Mixed Anhydrides with Diphenylphosphinic Acid for the Formation of Carboxamides". . p. 385 - 387. Retrieved 2007/10/02.