BZ-Phe-NH2

Base Information

• Chemical Name: BZ-Phe-NH2
• CAS No.: 72150-35-7
• Molecular Formula: C16H16 N2 O2
• Molecular Weight: 268.315
• DSSTox Substance ID: DTXSID70426218
• Nikkaji Number: J1.428.976C
• Wikidata: Q82239179
• Mol file: 72150-35-7.mol

Synonyms:BZ-PHE-NH2;72150-35-7;(S)-N-(1-Amino-1-oxo-3-phenylpropan-2-yl)benzamide;N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]benzamide;Benzoyl-L-phenylalanine amide;Bz-L-Phe-NH2;Na -Benzoyl-L-phenylalanine amide;Benzoylphenylalaninamid;SCHEMBL17244326;DTXSID70426218;Nalpha-Benzoyl-L-phenylalaninamide;MFCD00080883;N-alpha-Benzoyl-L-phenylalanine amide;AKOS027327903;AS-46949;Benzenepropanamide,a-(benzoylamino)-,(as)-;(2S)-2-(Benzoylamino)-3-phenylpropionamide;CS-0357497;F11011;(2S)-3-PHENYL-2-(PHENYLFORMAMIDO)PROPANAMIDE

Chemical Property of BZ-Phe-NH2

Chemical Property:

• PSA: 72.19000
• LogP: 2.60420
• Storage Temp.: Store at RT.
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 268.121177757
• Heavy Atom Count: 20
• Complexity: 331

Purity/Quality:

99% ^*data from raw suppliers

Bz-L-Phe-NH2 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CC(C(=O)N)NC(=O)C2=CC=CC=C2
• Isomeric SMILES: C1=CC=C(C=C1)C[C@@H](C(=O)N)NC(=O)C2=CC=CC=C2

Technology Process of BZ-Phe-NH2

There total 11 articles about BZ-Phe-NH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

C31H30N2O4 (1394992-03-0) → Bz-Phe-NH2 (72150-35-7)

Guidance literature:

With C₂₅H₂₆N₂O₄;

DOI:10.1021/ol302002g

Reference yield: 91.0%

C26H28N2O5 (1394992-01-8) → Bz-Phe-NH2 (72150-35-7)

Guidance literature:

With trifluoroacetic acid;

DOI:10.1021/ol302002g

Reference yield: 79.0%

Bz-Phe-Ser-OMe (131458-24-7) → Bz-Phe-NH2 (72150-35-7)

Guidance literature:

With ruthenium trichloride; sodium periodate; In tetrachloromethane; acetonitrile; for 1.5h; Ambient temperature; pH 3;

DOI:10.1021/ja00094a008

upstream raw materials:

Bz-Phe-Thr-OMe

Bz-Phe-Ser-OMe

N-benzoyl-L-phenylalanine

C₃₁H₃₀N₂O₄

Downstream raw materials:

N-Benzoyl-L-thiophenylalanin-O-ethylester

Refernces

• 1、 Takahashi, Daisuke,Yano, Tatsuya,Fukui, Tatsuya. "Novel diphenylmethyl-derived amide protecting group for efficient liquid-phase peptide synthesis: AJIPHASE". supporting information. p. 4514 - 4517. Retrieved 2012/10/29.
• 2、 Onuma, Ken-ichi,Ito, Tomiyasu,Nakamura, Asao. "Asymmetric Hydrogenation with Chiral Aminophosphine-Rhodium Complexes and Chiral Recognition by Bisphosphine-Rhodium Complexes in the Asymmetric Hydrogenation of Olefins through the Chiral Helical Conformation of Phenyl Groups on the Phosphorus Atom". . p. 2016 - 2019. Retrieved 2007/10/02.