Technology Process of (S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N-isopentyl-4-methylpentanamide lithium
There total 10 articles about (S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N-isopentyl-4-methylpentanamide lithium which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium hydroxide;
In
water; acetonitrile;
DOI:10.1021/jm401609a
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium carbonate; water / water / 20 °C
2: pyridine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
3: 3 h / Reflux
4: sodium hydroxide / 2 h / 20 °C
5: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 20 °C
6: lithium hydroxide / water; acetonitrile
With
pyridine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; sodium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hydroxide;
In
tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/jm401609a
- Guidance literature:
-
Multi-step reaction with 5 steps
1: pyridine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
2: 3 h / Reflux
3: sodium hydroxide / 2 h / 20 °C
4: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 20 °C
5: lithium hydroxide / water; acetonitrile
With
pyridine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hydroxide;
In
tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/jm401609a
