Technology Process of 3-(2-methylphenyl-2-chloropyrid-5-ylmethoxy)azetidine
There total 5 articles about 3-(2-methylphenyl-2-chloropyrid-5-ylmethoxy)azetidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-benzhydryl-3-(2-methylphenyl-2-chloropyrid-5-ylmethoxy)azetidine;
With
carbonochloridic acid 1-chloro-ethyl ester;
In
dichloromethane;
at 20 ℃;
for 18h;
With
methanol;
for 19h;
DOI:10.1016/j.bmcl.2011.12.032
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine / dichloromethane / 10 - 15 °C / Inert atmosphere
2.1: tetrahydrofuran; diethyl ether / 19.25 h / 5 - 20 °C / Inert atmosphere
3.1: sodium tetrahydroborate / methanol / 1.7 h
4.1: toluene-4-sulfonic acid / toluene / 4 h
5.1: carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 18 h / 20 °C
5.2: 19 h
With
sodium tetrahydroborate; carbonochloridic acid 1-chloro-ethyl ester; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene;
2.1: Grignard reaction;
DOI:10.1016/j.bmcl.2011.12.032
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: toluene-4-sulfonic acid / toluene / 4 h
2.1: carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 18 h / 20 °C
2.2: 19 h
With
carbonochloridic acid 1-chloro-ethyl ester; toluene-4-sulfonic acid;
In
dichloromethane; toluene;
DOI:10.1016/j.bmcl.2011.12.032
