FMOC-D-3-IODOPHENYLALANINE

Base Information

• Chemical Name: FMOC-D-3-IODOPHENYLALANINE
• CAS No.: 478183-67-4
• Molecular Formula: C₂₄H₂₀INO₄
• Molecular Weight: 513.332
• Hs Code.: 2924299090
• Mol file: 478183-67-4.mol

Synonyms:N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-iodo-D-phenylalanine;

Chemical Property of FMOC-D-3-IODOPHENYLALANINE

Chemical Property:

• Boiling Point: 658.8 °C at 760 mmHg
• Flash Point: 352.2 °C
• PSA: 75.63000
• Density: 1.577 g/cm³
• LogP: 5.21650
• Storage Temp.: Store at?0-5°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Fmoc-3-iodo-D-phenylalanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-D-3-IODOPHENYLALANINE

There total 1 articles about FMOC-D-3-IODOPHENYLALANINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1,1-dimethylethyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-iodo-L-phenylalaninate → (S)-2-((((9H-fluoren-9-yl)methoxy)-carbonyl)amino)-3-(3-iodophenyl)propanoic acid (210282-31-8,478183-67-4)

Guidance literature:

With trifluoroacetic acid; at 20 ℃;

DOI:10.1016/S0040-4020(01)00554-3

Reference yield:

(S)-2-((((9H-fluoren-9-yl)methoxy)-carbonyl)amino)-3-(3-iodophenyl)propanoic acid (210282-31-8,478183-67-4) → C20H18IN3O2

Guidance literature:

Multi-step reaction with 2 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C / Sealed tube

2: piperidine / acetonitrile / 20 h / 20 °C / Sealed tube

With piperidine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/chem.201601832

Reference yield:

(S)-2-((((9H-fluoren-9-yl)methoxy)-carbonyl)amino)-3-(3-iodophenyl)propanoic acid (210282-31-8,478183-67-4) → C23H22IN3O6

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.92 h

2: thionyl chloride / dichloromethane / 0 - 20 °C

With thionyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1002/anie.201608648