1-(3-METHOXY-PYRIDIN-2-YL)-PIPERAZINE

Base Information

• Chemical Name: 1-(3-METHOXY-PYRIDIN-2-YL)-PIPERAZINE
• CAS No.: 80827-67-4
• Molecular Formula: C10H15 N3 O
• Molecular Weight: 193.249
• Hs Code.: 2933990090
• Mol file: 80827-67-4.mol

Synonyms:1-(3-Methoxy-2-pyridinyl)piperazine;1-(3-Methoxy-2-pyridyl)piperazine

Chemical Property of 1-(3-METHOXY-PYRIDIN-2-YL)-PIPERAZINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 50.5-51.5 °C
• Boiling Point: 355.965°C at 760 mmHg
• PKA: 11.33±0.10(Predicted)
• Flash Point: 169.082°C
• PSA: 37.39000
• Density: 1.105g/cm³
• LogP: 0.89360
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

1-(3-Methoxypyridin-2-yl)piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-METHOXY-PYRIDIN-2-YL)-PIPERAZINE

There total 6 articles about 1-(3-METHOXY-PYRIDIN-2-YL)-PIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

→ 4-(3-methoxy-pyridin-2-yl)-piperazine (80827-67-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 20h;

Reference yield:

2-chloro-3-hydroxypyridine (6636-78-8) + methyl iodide (74-88-4) → 4-(3-methoxy-pyridin-2-yl)-piperazine (80827-67-4)

Guidance literature:

With sodium; In methanol; dimethyl sulfoxide;

Reference yield:

piperazine (110-85-0) + 2-bromo-pyridin-3-ol (6602-32-0) + NaCO3 + 2-bromo-3-methoxypyridine (24100-18-3) + CH3 I → 4-(3-methoxy-pyridin-2-yl)-piperazine (80827-67-4)

Guidance literature:

With hydrogenchloride; potassium hydroxide; In sodium hydroxide; water; dimethyl sulfoxide;

upstream raw materials:

piperazine

2-bromo-pyridin-3-ol

2-bromo-3-methoxypyridine

2-chloro-3-hydroxypyridine

Downstream raw materials:

1-(8-aza-bicyclo[3.2.1]oct-8-yl)-4-[4-(3-methoxy-pyridin-2-yl)-piperazin-1-yl]-2-phenyl-butan-1-one

Refernces

• 1、 Siebeneicher, Holger,Bauser, Marcus,Buchmann, Bernd,Heisler, Iring,Müller, Thomas,Neuhaus, Roland,Rehwinkel, Hartmut,Telser, Joachim,Zorn, Ludwig. "Identification of novel GLUT inhibitors". . p. 1732 - 1737. Retrieved 2016/07/27.
• 2、 -. "1-indolyalkyl-4-(substituted-pyridinyl)piperazines". . . Retrieved 2008/06/13.