Multi-step reaction with 4 steps
1.1: tert.-butyl lithium / tetrahydrofuran; pentane; Cyclopentane / 0.5 h / -78 °C
1.2: -78 - 20 °C
2.1: hydrogenchloride / methanol; water / 20 °C
3.1: Jones reagent / acetone / 0.5 h / 0 °C
4.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / N,N-dimethyl-formamide / 24 h / 20 °C
With
hydrogenchloride; Jones reagent; tert.-butyl lithium; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; Cyclopentane; water; N,N-dimethyl-formamide; acetone; pentane;
DOI:10.1016/j.bmc.2013.04.029