FMOC-D-ABU-OH

Base Information

• Chemical Name: FMOC-D-ABU-OH
• CAS No.: 170642-27-0
• Molecular Formula: C19H19NO4
• Molecular Weight: 325.364
• Hs Code.: 29214990
• Mol file: 170642-27-0.mol

Synonyms:Butanoicacid, 2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, (R)-;(R)-2-[[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]butanoic acid;Fmoc-D-2-aminobutyric acid;

Chemical Property of FMOC-D-ABU-OH

Chemical Property:

• Vapor Pressure: 5.83E-13mmHg at 25°C
• Refractive Index: 1.598
• Boiling Point: 550.7 °C at 760 mmHg
• PKA: 3.89±0.10(Predicted)
• Flash Point: 286.8 °C
• PSA: 75.63000
• Density: 1.255 g/cm³
• LogP: 3.77920
• Storage Temp.: Store at RT.

Purity/Quality:

99% ^*data from raw suppliers

Fmoc-D-Abu-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of FMOC-D-ABU-OH

There total 5 articles about FMOC-D-ABU-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

{(R)-1-[((1S,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-propyl}-carbamic acid 9H-fluoren-9-ylmethyl ester → (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)butanoic acid (170642-27-0)

Guidance literature:

With sulfuric acid; In 1,4-dioxane; water; for 8h; Heating;

DOI:10.1021/ja9624073

Reference yield: 65.0%

→ (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)butanoic acid (170642-27-0)

Guidance literature:

Reference yield:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) + (S,S)-pseudoephedrine D-2-aminobutyramide (170642-21-4) → pseudoephedrine (90-82-4,7009-81-6,90-83-5,6912-63-6) + (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)butanoic acid (170642-27-0)

Guidance literature:

With sodium hydroxide; sodium hydrogencarbonate; Yield given. Multistep reaction; 1.) reflux, 2.) 1.5 h;

DOI:10.1021/ja00137a034

upstream raw materials:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

(S,S)-pseudoephedrine D-2-aminobutyramide

(R)-2-aminobutyric acid

Refernces

• 1、 -. "Method for the synthesis of compounds of formula 1 and derivatives thereof". Page 15. . Retrieved 2008/06/13.
• 2、 Myers, Andrew G.,Gleason, James L.,Yoon, Taeyoung. "A practical method for the synthesis of D- or L-α-amino acids by the alkylation of (+)- or (-)-pseudoephedrine glycinamide". . p. 8488 - 8489. Retrieved 2007/10/02.