TRANS-2-BROMO-1-INDANOL

Base Information

• Chemical Name: TRANS-2-BROMO-1-INDANOL
• CAS No.: 10368-44-2
• Molecular Formula: C9H9 Br O
• Molecular Weight: 213.074
• Hs Code.: 29062990
• Mol file: 10368-44-2.mol

Synonyms:1-Indanol,2-bromo-, trans- (8CI); 1H-Inden-1-ol, 2-bromo-2,3-dihydro-, trans-; (?à)-trans-2-Bromoindanol; Trans-(?à)-2-Bromoindan-1-ol;trans-2-Bromoindan-1-ol

Chemical Property of TRANS-2-BROMO-1-INDANOL

Chemical Property:

• Vapor Pressure: 0.000152mmHg at 25°C
• Melting Point: 130-131 °C(lit.)
• Boiling Point: 318.3ºC at 760 mmHg
• PKA: 13.19±0.40(Predicted)
• Flash Point: 146.3ºC
• PSA: 20.23000
• Density: 1.64g/cm3
• LogP: 2.03960
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(1R,2R)-2-bromo-2,3-dihydro-1h-inden-1-ol ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TRANS-2-BROMO-1-INDANOL

There total 10 articles about TRANS-2-BROMO-1-INDANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.6%

1-indene (95-13-6) → trans-2-bromo-1-indanol (10368-44-2,78684-69-2)

Guidance literature:

With N-Bromosuccinimide; In tetrahydrofuran; water; at 20 ℃; for 24h;

DOI:10.1002/adsc.200404296

Reference yield: 95.0%

trans-1,2-bromoindane (19598-15-3) → trans-2-bromo-1-indanol (10368-44-2,78684-69-2)

Guidance literature:

With silica gel; In hexane; at 20 ℃; for 168h;

Reference yield: 86.0%

1-indene (95-13-6) → trans-1,2-bromoindane (19598-15-3) + trans-2-bromo-1-indanol (10368-44-2,78684-69-2)

Guidance literature:

With Oxone; ammonium bromide; In water; acetonitrile; at 20 ℃; for 0.0166667h; stereoselective reaction;

DOI:10.1016/j.tetlet.2012.01.026

upstream raw materials:

1-indene

trans-1,2-bromoindane

1-bromoindane

1-Indanol

Downstream raw materials:

(+/-)-cis-2-phenylsulfanyl-indan-1-ol

trans-2-phenylmercapto-1-indanol

2,3-epoxyindene

indan-2-ol

Refernces

• 1、 Mc Ewen, Ian,R?nnqvist, Mats,Ahlberg, Per. "Hydrogen bonding of hydroxy groups to carbanions in indenide and fluorenide derivatized alcohols directly observed by UV, IR, and NMR spectroscopy". . p. 3989 - 3996. Retrieved 1993.
• 2、 Gómez, Matías E.,Gentile, Emiliano A.,Florencia Martini,Cuestas, María L.,Mathet, Verónica L.,Moltrasio, Graciela Y.,Moglioni, Albertina G.. "Synthesis of new indanyl nucleoside analogues and their biological evaluation on hepatitis C virus (HCV) replicon". . . Retrieved 2019.
• 3、 Song, Song,Huang, Xiaoqiang,Liang, Yu-Feng,Tang, Conghui,Li, Xinwei,Jiao, Ning. "From simple organobromides or olefins to highly value-added bromohydrins: A versatile performance of dimethyl sulfoxide". . p. 2727 - 2731. Retrieved 2015.
• 4、 Seitz, Jakob,Wirth, Thomas. "Electrochemical bromofunctionalization of alkenes in a flow reactor". supporting information. p. 6892 - 6896. Retrieved 2021/08/20.