2,3-Dichloro-4-hydroxybenzaldehyde

Base Information

• Chemical Name: 2,3-Dichloro-4-hydroxybenzaldehyde
• CAS No.: 16861-22-6
• Molecular Formula: C7H4Cl2O2
• Molecular Weight: 191.014
• Hs Code.: 2913000090
• Mol file: 16861-22-6.mol

Synonyms:2,3-Dichloro-4-hydroxybenzaldehyde;Benzaldehyde, 2,3-dichloro-4-hydroxy;

Chemical Property of 2,3-Dichloro-4-hydroxybenzaldehyde

Chemical Property:

• Vapor Pressure: 0.00249mmHg at 25°C
• Melting Point: 184-185 °C
• Refractive Index: 1.643
• Boiling Point: 278.629 °C at 760 mmHg
• PKA: 5.36±0.23(Predicted)
• Flash Point: 122.311 °C
• PSA: 37.30000
• Density: 1.548 g/cm³
• LogP: 2.51150

Purity/Quality:

99% ^*data from raw suppliers

2,3-dichloro-4-hydroxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-Dichloro-4-hydroxybenzaldehyde

There total 5 articles about 2,3-Dichloro-4-hydroxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

chloroform (67-66-3,8013-54-5) + 2,3-dichlorophenol (576-24-9) → 2,3-dichloro-4-hydroxybenzaldehyde (16861-22-6)

Guidance literature:

With calcium hydroxide; sodium carbonate; In water; for 2h; Heating;

DOI:10.1021/je00031a039

Reference yield:

2,3-dichloro-4-methoxy-benzaldehyde (41827-86-5) → 2,3-dichloro-4-hydroxybenzaldehyde (16861-22-6)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2004.03.028

Reference yield:

2,3-dichloroanisole (1984-59-4) → 2,3-dichloro-4-hydroxybenzaldehyde (16861-22-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / TiCl₄ / CH₂Cl₂ / 5 h / 20 °C

2: boron tribromide / CH₂Cl₂ / 0 - 20 °C

With boron tribromide; titanium tetrachloride; In dichloromethane;

DOI:10.1016/j.bmc.2004.03.028

upstream raw materials:

chloroform

2,3-dichlorophenol

2,3-dichloro-4-methoxy-benzaldehyde

2,3-dichloroanisole

Downstream raw materials:

ethyl <2,3-dichloro-4-formylphenoxy> acetate

Refernces

• 1、 -. "HYDROXY-BIPHENYL-CARBALDEHYDE OXIME DERIVATIVES AND THEIR USE AS ESTROGENIC AGENTS". Page 18; 38-39. . Retrieved 2008/06/13.
• 2、 -. "Phenoxyacetic acid derivatives composition and use". . . Retrieved 2008/06/13.