VRX-480773

Base Information

• Chemical Name: VRX-480773
• CAS No.: 878670-89-4
• Molecular Formula: C₂₃H₁₉BrClN₅O₃S₂
• Molecular Weight: 592.925
• Mol file: 878670-89-4.mol

Synonyms:VRX-480773

Chemical Property of VRX-480773

Chemical Property:

Purity/Quality:

98% HPLC ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of VRX-480773

There total 1 articles about VRX-480773 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

2-{[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acid (878672-00-5) + 4-amino-3-chlorobenzenesulfonamide (53297-68-0) → VRX-480773 (878670-89-4)

Guidance literature:

2-{[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acid; 4-amino-3-chlorobenzenesulfonamide; With trichlorophosphate; In pyridine; at 0 ℃; for 0.916667h;

With water; In pyridine; Product distribution / selectivity;

Reference yield: 82.0%

VRX-480773 (878670-89-4) → 2-{[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acid (878672-00-5)

Guidance literature:

VRX-480773; With sodium hydroxide; water; In ethanol; at 20 ℃; for 16h; Heating / reflux;

With hydrogenchloride; In water; at 0 ℃; Product distribution / selectivity;

Reference yield: 65.0%

VRX-480773 (878670-89-4) + N,N'-bis(tert-butyloxycarbonyl)-L-lysine dicyclohexylamine salt → 2-[5-bromo-4-(4-cyclopropyl-naphthaIen-1-yl)-4H-[1,2,4]triazol-3-ylsulfanyl]-N-(2-chIoro-4-propionylsulfamoyl-phenyl)lysinamide

Guidance literature:

VRX-480773; N,N'-bis(tert-butyloxycarbonyl)-L-lysine dicyclohexylamine salt; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; at 20 ℃; for 14h;

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 14h;

upstream raw materials:

2-{[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acid

4-amino-3-chlorobenzenesulfonamide

Downstream raw materials:

2-{[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acid

Refernces