1,3-Dichloro-2,4-difluoro-5-nitrobenzene

Base Information

• Chemical Name: 1,3-Dichloro-2,4-difluoro-5-nitrobenzene
• CAS No.: 15952-70-2
• Molecular Formula: C6HCl2F2NO2
• Molecular Weight: 227.982
• Hs Code.: 2904909090
• DSSTox Substance ID: DTXSID70378829
• Wikidata: Q72462854
• Mol file: 15952-70-2.mol

Synonyms:1,3-dichloro-2,4-difluoro-5-nitrobenzene;15952-70-2;3,5-DICHLORO-2,4-DIFLUORONITROBENZENE;3, 5-Dichloro-2,4-difluoronitrobenzene;2,4-Difluoro-3,5-dichloronitrobenzene;C6HCl2F2NO2;MFCD03094441;SCHEMBL9343855;DTXSID70378829;AKOS015890100;AC-9704;AM61790;DS-1371;CS-0320867;FT-0602469;A20572;Benzene, 1,3-dichloro-2,4-difluoro-5-nitro-

Chemical Property of 1,3-Dichloro-2,4-difluoro-5-nitrobenzene

Chemical Property:

• Vapor Pressure: 0.013mmHg at 25°C
• Refractive Index: 1.55
• Boiling Point: 268 °C at 760 mmHg
• Flash Point: 115.9 °C
• PSA: 45.82000
• Density: 1.706 g/cm³
• LogP: 3.70300
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 226.9352400
• Heavy Atom Count: 13
• Complexity: 213

Purity/Quality:

98% ^*data from raw suppliers

3,5-Dichloro-2,4-difluoronitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=C(C(=C1Cl)F)Cl)F)[N+](=O)[O-]

Technology Process of 1,3-Dichloro-2,4-difluoro-5-nitrobenzene

There total 7 articles about 1,3-Dichloro-2,4-difluoro-5-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3,5-dichloro-2,4-difluoro-aniline (83121-15-7) → 2,4-difluoro-3,5-dichloro-nitrobenzene (15952-70-2)

Guidance literature:

With phosphoric acid; 3 % platinum on carbon; hydrogen; In methanol; at 75 - 80 ℃; for 6h; under 1500.15 - 11251.1 Torr; Pressure; Reagent/catalyst; Solvent; Temperature; Autoclave;

Reference yield: 91.0%

2,3,4,5-tetrachloronitrobenzene (879-39-0) → 2,4-difluoro-3,5-dichloro-nitrobenzene (15952-70-2)

Guidance literature:

With potassium fluoride; tetrabutylammomium bromide; In sulfolane; toluene; at 135 ℃; for 16h;

Reference yield:

2,3-dichloro-1-fluoro-4-nitrobenzene (36556-51-1) → 2,4-difluoro-3,5-dichloro-nitrobenzene (15952-70-2)

Guidance literature:

2,3-dichloro-1-fluoro-4-nitrobenzene; With sulfuric acid; nitric acid; at 50 - 60 ℃; for 3h;

With iron(III) chloride; chlorine; sodium iodide; at 60 - 70 ℃; for 30h;

With potassium fluoride; tetrabutylammomium bromide; at 150 - 160 ℃; for 12h;

upstream raw materials:

2,3,4,5-tetrachloronitrobenzene

1,2,3-trichlorobenzene

4-nitro-1,2,3-trichlorobenzene

2,3,4-trichloroaniline

Downstream raw materials:

3,5-dichloro-2,4-difluoro-aniline

1,3,5-trichlorotrifluorobenzene

1,3,5-trichloro-2,4-difluorobenzene

Refernces

• 1、 -. "Method for preparing teflubenzuron intermediate 3,5-dichloro-2,4-difluoroaniline". Paragraph 0040-0043; 0045-0048; 0050-0053; 0055. . Retrieved 2019/03/08.
• 2、 -. "Process for obtaining substituted fluorobenzenes". . . Retrieved 2008/06/13.