Technology Process of 4-{[ethyl-(4-methylcoumarin-7-yl)amino]methyl}benzoic acid
There total 8 articles about 4-{[ethyl-(4-methylcoumarin-7-yl)amino]methyl}benzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-{[ethyl-(4-methylcoumarin-7-yl)amino]methyl}benzoic acid methyl ester;
With
tetra(n-butyl)ammonium hydroxide;
In
tetrahydrofuran; water;
at 20 ℃;
With
hydrogenchloride;
In
tetrahydrofuran; water;
DOI:10.1016/j.dyepig.2011.08.020
- Guidance literature:
-
Multi-step reaction with 5 steps
1: pyridine / dichloromethane / 20 °C
2: caesium carbonate / acetonitrile / 80 °C
3: sulfuric acid / 12 h / 90 °C
4: potassium carbonate / acetonitrile / 72 h / Reflux
5: tetra(n-butyl)ammonium hydroxide / tetrahydrofuran; water / 20 °C
With
pyridine; sulfuric acid; tetra(n-butyl)ammonium hydroxide; potassium carbonate; caesium carbonate;
In
tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1016/j.dyepig.2011.08.020
- Guidance literature:
-
Multi-step reaction with 8 steps
1: ethyl acetate / Reflux
2: sulfuric acid / 0 °C
3: sulfuric acid; acetic acid / Reflux
4: pyridine / dichloromethane / 20 °C
5: caesium carbonate / acetonitrile / 80 °C
6: sulfuric acid / 12 h / 90 °C
7: potassium carbonate / acetonitrile / 72 h / Reflux
8: tetra(n-butyl)ammonium hydroxide / tetrahydrofuran; water / 20 °C
With
pyridine; sulfuric acid; tetra(n-butyl)ammonium hydroxide; potassium carbonate; caesium carbonate; acetic acid;
In
tetrahydrofuran; dichloromethane; water; ethyl acetate; acetonitrile;
DOI:10.1016/j.dyepig.2011.08.020