Technology Process of ethyl 6-bromo-2-((4-fluorophenylthio)methyl)-8-hydroxyimidazo[1,2-a]pyridine-3-carboxylate
There total 6 articles about ethyl 6-bromo-2-((4-fluorophenylthio)methyl)-8-hydroxyimidazo[1,2-a]pyridine-3-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogenchloride; acetic acid / water / Reflux; Inert atmosphere
2.1: ethanol / Reflux
3.1: potassium hydroxide / 0 °C
3.2: 20 °C
With
hydrogenchloride; acetic acid; potassium hydroxide;
In
ethanol; water;
DOI:10.1002/ardp.201000045
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tetrabutylammomium bromide; sodium hydroxide / dichloromethane; water / 6 h / 20 °C
2.1: sulfuric acid; bromine; acetic acid / water / 0 - 20 °C
3.1: hydrogenchloride; acetic acid / water / Reflux; Inert atmosphere
4.1: ethanol / Reflux
5.1: potassium hydroxide / 0 °C
5.2: 20 °C
With
hydrogenchloride; sulfuric acid; tetrabutylammomium bromide; bromine; acetic acid; potassium hydroxide; sodium hydroxide;
In
ethanol; dichloromethane; water;
DOI:10.1002/ardp.201000045
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sulfuryl dichloride / dichloromethane / 12 h / 20 °C
2.1: ethanol / Reflux
3.1: potassium hydroxide / 0 °C
3.2: 20 °C
With
sulfuryl dichloride; potassium hydroxide;
In
ethanol; dichloromethane;
DOI:10.1002/ardp.201000045