Technology Process of C25H22BrN3O2
There total 7 articles about C25H22BrN3O2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-bromo-1-(6-bromonaphthalen-2-yl)ethanone; N-Benzyloxycarbonyl-L-proline;
With
N-ethyl-N,N-diisopropylamine;
In
acetonitrile;
at 20 ℃;
for 0.666667h;
With
ammonium acetate;
In
toluene;
Reflux;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane
2.1: potassium carbonate / dichloromethane; water / 1 h
3.1: tetrahydrofuran; 2-methyltetrahydrofuran / 1.5 h / 10 - 15 °C / Inert atmosphere
3.2: Cooling with ice
4.1: bromine / dichloromethane / 1.5 h
5.1: triethylamine; phosphonic acid diethyl ester / tetrahydrofuran
6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.67 h / 20 °C
6.2: Reflux
With
oxalyl dichloride; bromine; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; phosphonic acid diethyl ester;
N,N-dimethyl-formamide;
In
tetrahydrofuran; 2-methyltetrahydrofuran; dichloromethane; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / dichloromethane; water / 1 h
2.1: tetrahydrofuran; 2-methyltetrahydrofuran / 1.5 h / 10 - 15 °C / Inert atmosphere
2.2: Cooling with ice
3.1: bromine / dichloromethane / 1.5 h
4.1: triethylamine; phosphonic acid diethyl ester / tetrahydrofuran
5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.67 h / 20 °C
5.2: Reflux
With
bromine; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; phosphonic acid diethyl ester;
In
tetrahydrofuran; 2-methyltetrahydrofuran; dichloromethane; water; acetonitrile;