2-methoxy-6-phenylisonicotinic acid

Base Information

• Chemical Name: 2-methoxy-6-phenylisonicotinic acid
• CAS No.: 1041204-92-5
• Molecular Formula: C₁₃H₁₁NO₃
• Molecular Weight: 229.235
• Mol file: 1041204-92-5.mol

Synonyms:2-methoxy-6-phenylisonicotinic acid

Chemical Property of 2-methoxy-6-phenylisonicotinic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-methoxy-6-phenylisonicotinic acid

There total 6 articles about 2-methoxy-6-phenylisonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 2-methoxy-6-phenylisonicotinate → 2-methoxy-6-phenylisonicotinic acid (1041204-92-5)

Guidance literature:

With lithium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 16h;

DOI:10.1016/j.ejmech.2016.03.020

Reference yield:

2-chloro-6-methoxyisonicotinic acid methyl ester (42521-10-8) → 2-methoxy-6-phenylisonicotinic acid (1041204-92-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 18 h / 80 °C / Inert atmosphere

2: lithium hydroxide / water; 1,4-dioxane / 16 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; lithium hydroxide; In 1,4-dioxane; 1,2-dimethoxyethane; water; 1: |Suzuki Coupling;

DOI:10.1016/j.ejmech.2016.03.020

Reference yield:

methyl 2-chloro-6-phenylpyridine-4-carboxylate (925004-76-8) + sodium methylate (124-41-4) → 2-methoxy-6-phenylisonicotinic acid (1041204-92-5)

Guidance literature:

In methanol; ISOPROPYLAMIDE; at 20 - 130 ℃;

upstream raw materials:

methyl 2-chloro-6-phenylpyridine-4-carboxylate

sodium methylate

citrazinic acid

2,6-dibromoisonicotinic acid

Downstream raw materials:

1'-{[2-methoxy-6-phenylpyridin-4-yl]carbonyl}-6-(tetrazol-5-yl)-spiro[chroman-2,4'-piperidin]-4-one

Refernces

• 1、 Bolli, Martin H.,Lescop, Cyrille,Birker, Magdalena,De Kanter, Ruben,Hess, Patrick,Kohl, Christopher,Nayler, Oliver,Rey, Markus,Sieber, Patrick,Velker, J?rg,Weller, Thomas,Steiner, Beat. "Novel S1P1 receptor agonists - Part 5: From amino-to alkoxy-pyridines". supporting information. p. 326 - 341. Retrieved 2016/04/19.