2',3'-Difluoroacetophenone

Base Information

• Chemical Name: 2',3'-Difluoroacetophenone
• CAS No.: 18355-80-1
• Molecular Formula: C8H6F2O
• Molecular Weight: 156.132
• Hs Code.: 2914700090
• Mol file: 18355-80-1.mol

Synonyms:Acetophenone, 2',3'-difluoro- (8CI);1-(2,3-Difluorophenyl)ethanone;2,3-Difluoroacetophenone;2',3'-Difluoroacetophenone;

Chemical Property of 2',3'-Difluoroacetophenone

Chemical Property:

• Vapor Pressure: 0.465mmHg at 25°C
• Refractive Index: 1.489
• Boiling Point: 193.431 °C at 760 mmHg
• Flash Point: 71.455 °C
• PSA: 17.07000
• Density: 1.207 g/cm³
• LogP: 2.16740

Purity/Quality:

98%,99%, ^*data from raw suppliers

2'',3''-Difluoroacetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-22
• Safety Statements: 26-36-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2'',3''-Difluoroacetophenone

Technology Process of 2',3'-Difluoroacetophenone

There total 3 articles about 2',3'-Difluoroacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

fluorosulphonic acid (7789-21-1) + acetophenone (98-86-2) → 2'-Fluoroacetophenone (445-27-2) + 2,3-difluoroacetophenone (18355-80-1)

Guidance literature:

at 110 ℃;

Reference yield:

(+/-)-1-(2,3-difluorophenyl)ethanol (1228690-56-9) → (R)-(+)-1-(2,3-difluorophenyl)ethanol + 2,3-difluoroacetophenone (18355-80-1)

Guidance literature:

(+/-)-1-(2,3-difluorophenyl)ethanol; With C₂₈H₃₆ClMnN₂O₂; potassium acetate; In dichloromethane; water; for 0.0833333h;

With N-Bromosuccinimide; In dichloromethane; water; at 20 ℃; for 4h; enantioselective reaction; Kinetics;

DOI:10.1039/c2ob07087a

Reference yield:

→ 2,3-difluoroacetophenone (18355-80-1)

Guidance literature:

2,3-Difluorbenzoylchlorid, Di-Etethoxymagnesiomalonat;

upstream raw materials:

fluorosulphonic acid

acetophenone

(+/-)-1-(2,3-difluorophenyl)ethanol

Downstream raw materials:

N-<1-(2,3-difluorophenyl)ethylidene>-2-(trifluoromethyl)aniline

Diethyl 2-[2-(2,3-difluorophenyl)-2-oxoethyl]-2-hydroxymalonate

(+/-)-1-(2,3-difluorophenyl)ethanol

Refernces