C₁₉H₁₉N₅O

Base Information

• Chemical Name: C₁₉H₁₉N₅O
• CAS No.: 1423172-04-6
• Molecular Formula: C₁₉H₁₉N₅O
• Molecular Weight: 333.393
• Mol file: 1423172-04-6.mol

Synonyms:C₁₉H₁₉N₅O

Chemical Property of C₁₉H₁₉N₅O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₁₉N₅O

There total 6 articles about C₁₉H₁₉N₅O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

N-methyl-p-phenetidine (3154-18-5) + N-(4-chloro-9H-pyrimido[4,5-b]indol-2-yl)-2,2-dimethylpropanamide (1133824-77-7) → C19H19N5O (1423172-04-6)

Guidance literature:

With hydrogenchloride; In water; isopropyl alcohol; for 120h; Reflux;

DOI:10.1016/j.bmc.2012.12.010

Reference yield:

2-amino-3,5,6,7,8,9-hexahydro-4H-pyrimido[4,5-b]indol-4-one → C19H19N5O (1423172-04-6)

Guidance literature:

Multi-step reaction with 4 steps

1: palladium 10% on activated carbon / diphenylether / 3 h / Reflux

2: dmap / N,N-dimethyl-formamide / 40 h / 60 °C

3: trichlorophosphate / 4 h / Reflux

4: hydrogenchloride / water; isopropyl alcohol / 120 h / Reflux

With hydrogenchloride; dmap; palladium 10% on activated carbon; trichlorophosphate; In diphenylether; water; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.bmc.2012.12.010

Reference yield:

4-Ethoxyaniline (156-43-4) → C19H19N5O (1423172-04-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium methylate / methanol / 5 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate / methanol / 2 h / Inert atmosphere; Reflux

3: hydrogenchloride / water; isopropyl alcohol / 120 h / Reflux

With hydrogenchloride; sodium tetrahydroborate; sodium methylate; In methanol; water; isopropyl alcohol;

DOI:10.1016/j.bmc.2012.12.010

upstream raw materials:

2-amino-1,9-hydroxy-4H-pyrimido[4,5-b]indol-4-one

2,2-dimethyl-N-(4-oxo-4,9-dihydro-3H-pyrimido[4,5-b]indol-2-yl)propanamide

N-methyl-p-phenetidine

N-(4-chloro-9H-pyrimido[4,5-b]indol-2-yl)-2,2-dimethylpropanamide

Refernces