2-STYRYLINDOLE

Base Information

• Chemical Name: 2-STYRYLINDOLE
• CAS No.: 29475-88-5
• Molecular Formula: C16H13N
• Molecular Weight: 219.286
• Mol file: 29475-88-5.mol

Synonyms:1H-Indole,2-(2-phenylethenyl)-, (E)-;Indole, 2-styryl-, (E)- (8CI);

Chemical Property of 2-STYRYLINDOLE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.757
• Boiling Point: 409.885 °C at 760 mmHg
• Flash Point: 182.303 °C
• PSA: 15.79000
• Density: 1.185 g/cm³
• LogP: 4.33830

Purity/Quality:

99% ^*data from raw suppliers

2-STYRYLINDOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-STYRYLINDOLE

There total 42 articles about 2-STYRYLINDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(E)-1-(pyrimidin-2-yl)-2-styryl-1H-indole → trans-2-styrylindole (29475-88-5)

Guidance literature:

With sodium ethanolate; In dimethyl sulfoxide; at 100 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c4cc06036a

Reference yield: 85.0%

(E)-triethyl((4-phenylbuta-1,3-dien-2-yl)oxy)silane + 2-iodophenylamine (615-43-0) → trans-2-styrylindole (29475-88-5)

Guidance literature:

With 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate; tributyltin fluoride; cesium fluoride; regioselective reaction; Inert atmosphere; Heating;

DOI:10.1021/acs.orglett.5b00324

Reference yield: 82.0%

(E)-N-(2-pyridylsulfonyl)-2-styrylindole (1190425-92-3) → trans-2-styrylindole (29475-88-5)

Guidance literature:

With ammonium chloride; zinc; In tetrahydrofuran; water; at 20 ℃; Inert atmosphere;

DOI:10.1002/anie.200902802

upstream raw materials:

3-methyl-1,5-diphenyl-4,5-dihydro-1H-pyrazole

benzaldehyde

(1-methoxycarbonylindol-2-yl)methyl(triphenyl)phosphonium bromide

Triphenyl-{2-[(E)-(3-phenyl-acryloyl)amino]-benzyl}-phosphonium; bromide

Downstream raw materials:

2-Phenyl-3,3,4,4-tetracyano-1,2,3,4-tetrahydro-9H-carbazole

methyl 2β-phenyl-1,2,3,4-tetrahydro-9H-carbazole-3β-carboxylate

Refernces

• 1、 Huang, Lin-Jie,Weng, Jiang,Wang, Sheng,Lu, Gui. "Organocatalytic diels-alder reaction of 2-vinylindoles with methyleneindolinones: An efficient approach to functionalized carbazolespirooxindoles". . p. 993 - 1003. Retrieved 2015.
• 2、 Bzeih, Tourin,Zhang, Kena,Khalaf, Ali,Hachem, Ali,Alami, Mouad,Hamze, Abdallah. "One-Pot Reaction between N-Tosylhydrazones and 2-Nitrobenzyl Bromide: Route to NH-Free C2-Arylindoles". . p. 228 - 238. Retrieved 2019/01/04.