SODIUM 3-METHOXY-3-OXOPROPANE-1-SULFINATE

Base Information

• Chemical Name: SODIUM 3-METHOXY-3-OXOPROPANE-1-SULFINATE
• CAS No.: 90030-48-1
• Molecular Formula: C4H8 O4 S . Na
• Molecular Weight: 174.153
• Mol file: 90030-48-1.mol

Synonyms:Propanoicacid, 3-sulfino-, 1-methyl ester, sodium salt (9CI); Propionic acid,3-sulfino-, methyl ester, sodium salt (7CI); 3-Sulfinopropanoic acid 1-methylester sodium salt; Sodium 3-methoxy-3-oxopropan-1-sulfinate; Sodium3-methoxy-3-oxopropane-1-sulfinate

Chemical Property of SODIUM 3-METHOXY-3-OXOPROPANE-1-SULFINATE

Chemical Property:

• Vapor Pressure: 2.52E-05mmHg at 25°C
• Melting Point: 199-216°C (decomposition)
• Boiling Point: 334°Cat760mmHg
• Flash Point: 155.8°C
• PSA: 85.64000
• Density: g/cm³
• LogP: 0.29430
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

Sodium 1-methyl 3-sulfinopropanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Reagent facilitates the conversion of aryl and benzyl halides to their corresponding sulfonimides under basic conditions.

Technology Process of SODIUM 3-METHOXY-3-OXOPROPANE-1-SULFINATE

There total 3 articles about SODIUM 3-METHOXY-3-OXOPROPANE-1-SULFINATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl 3-[(3-oxobutyl)sulfonyl]propanoate (502635-00-9) → sodium 3-methoxy-3-oxo-propane-1-sulfinate (90030-48-1)

Guidance literature:

With sodium methylate; In tetrahydrofuran; methanol; at 20 ℃; for 0.25h;

DOI:10.1016/S0040-4039(02)02073-7

Reference yield:

methyl 3-(chlorosulfonyl)propanoate (15441-07-3) → sodium 3-methoxy-3-oxo-propane-1-sulfinate (90030-48-1)

Guidance literature:

With sodium hydrogencarbonate; sodium sulfite; In water; at 80 ℃; for 4h;

DOI:10.1021/acs.orglett.6b02289

Reference yield:

→ sodium 3-methoxy-3-oxo-propane-1-sulfinate (90030-48-1)

Guidance literature:

upstream raw materials:

methyl 3-[(3-oxobutyl)sulfonyl]propanoate

methyl 3-(chlorosulfonyl)propanoate

Downstream raw materials:

3-[5-({[1-(4-fluorophenyl)-1H-pyrazolo[3,4-c]pyridine-4-carbonyl]-amino}-methyl)-pyridine-2-sulfonyl]-propionic acid methyl ester

Refernces

• 1、 Du, Bingnan,Qian, Ping,Wang, Yang,Mei, Haibo,Han, Jianlin,Pan, Yi. "Cu-Catalyzed Deoxygenative C2-Sulfonylation Reaction of Quinoline N-Oxides with Sodium Sulfinate". supporting information. p. 4144 - 4147. Retrieved 2016/08/30.
• 2、 Baskin, Jeremy M,Wang, Zhaoyin. "A mild, convenient synthesis of sulfinic acid salts and sulfonamides from alkyl and aryl halides". . p. 8479 - 8483. Retrieved 2007/10/03.