(-)-(1R,2S)-N,O-dimethylephedrine

Base Information Edit

Chemical Name:(-)-(1R,2S)-N,O-dimethylephedrine
CAS No.:46288-71-5
Molecular Formula:C₁₂H₁₉NO
Molecular Weight:193.289
Hs Code.:
Mol file:46288-71-5.mol

Synonyms:(-)-(1R,2S)-N,O-dimethylephedrine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (-)-(1R,2S)-N,O-dimethylephedrine Edit

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Technology Process of (-)-(1R,2S)-N,O-dimethylephedrine

There total 3 articles about (-)-(1R,2S)-N,O-dimethylephedrine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 552-79-4
(-)-N-methylephedrine

: 74-88-4
methyl iodide

: 46288-71-5
(-)-(1R,2S)-N,O-dimethylephedrine

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 96h;
DOI:10.1016/S0957-4166(01)00344-5

Reference yield:

: 299-42-3,7009-81-6,90-83-5,6912-63-6
ephedrine

: 46288-71-5
(-)-(1R,2S)-N,O-dimethylephedrine

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / formic acid / H₂O / 3 h / Heating

2: 1.) KH / 1.) THF, reflux, 2.) 20 deg C, 1 h

With formic acid; potassium hydride; In water;
DOI:10.1016/S0957-4166(00)80447-4

Reference yield:

: 42151-56-4
(1S,2R)-(+)-N-methylephedrine

: 74-88-4
methyl iodide

: 2226-33-7,46288-71-5,79297-94-2,79297-97-5,82950-54-7,133161-06-5
(1R,2S)-(-)-N-methylephedrine methyl ether

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction; 1.) THF, HMPT, -70 deg C, 30 min, 2.) THF, HMPT, 45 deg C, 4 h;
DOI:10.1021/jo00384a028