2-fluorophenyl-2-iodophenyl thio ether

Base Information

• Chemical Name: 2-fluorophenyl-2-iodophenyl thio ether
• CAS No.: 908242-65-9
• Molecular Formula: C₁₂H₈FIS
• Molecular Weight: 330.164
• Mol file: 908242-65-9.mol

Synonyms:2-fluorophenyl-2-iodophenyl thio ether

Chemical Property of 2-fluorophenyl-2-iodophenyl thio ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-fluorophenyl-2-iodophenyl thio ether

There total 7 articles about 2-fluorophenyl-2-iodophenyl thio ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1,2-Diiodobenzene (615-42-9) + 2-fluorothiophenol (2557-78-0) → 2-fluorophenyl-2-iodophenyl thio ether (908242-65-9)

Guidance literature:

With sodium hydride; In tetrahydrofuran; N,N-dimethyl acetamide; at 20 ℃; for 10h; Solvent; Reagent/catalyst; Temperature;

Reference yield: 72.0%

2-Amino-2'-fluorodiphenyl Sulfide (98796-24-8) → 2-fluorophenyl-2-iodophenyl thio ether (908242-65-9)

Guidance literature:

2-Amino-2'-fluorodiphenyl Sulfide; With sulfuric acid; sodium nitrite; In water; for 0.5h; cooling;

With copper; potassium iodide; In water; for 0.5h; Heating;

DOI:10.1021/jo060911c

Reference yield: 65.0%

o-fluorobromobenzene (1072-85-1) + 2-fluorothiophenol (2557-78-0) → 2-fluorophenyl-2-iodophenyl thio ether (908242-65-9)

Guidance literature:

2-fluorothiophenol; With isopropylmagnesium chloride; In tetrahydrofuran; at 80 ℃; Inert atmosphere;

o-fluorobromobenzene; In tetrahydrofuran; at 80 ℃; Inert atmosphere;

With iodine; In tetrahydrofuran; at 20 ℃; Inert atmosphere; Reflux;

DOI:10.1039/d0ob01839b

upstream raw materials:

2-Amino-2'-fluorodiphenyl Sulfide

2-fluorothiophenol

2-fluorophenyl 2-nitrophenyl thioether

2-Chloronitrobenzene

Downstream raw materials:

dibenzothiophene

1-bromodibenzo[b,d]thiophene

1-phenylthiodibenzothiophene

Refernces

• 1、 -. "Reaction method of thiophenol and O-diiodobenzene". Paragraph 0014-0016; 0037-0039. . Retrieved 2021/11/10.
• 2、 -. "Compound Containing At Least Two 5-Membered Heterocycle And Organic Electronic Element Using The Same, Terminal Thereof". Paragraph 0105-0108. . Retrieved 2016/11/09.