C₂₇H₂₃N

Base Information

• Chemical Name: C₂₇H₂₃N
• CAS No.: 1620789-28-7
• Molecular Formula: C₂₇H₂₃N
• Molecular Weight: 361.486
• Mol file: 1620789-28-7.mol

Synonyms:C₂₇H₂₃N

Chemical Property of C₂₇H₂₃N

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₂₃N

There total 5 articles about C₂₇H₂₃N which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

C28H27NO (1620789-27-6) → C27H23N (1620789-28-7)

Guidance literature:

With methanesulfonic acid; In dichloromethane; at 20 ℃; for 17h;

Reference yield:

1,6-dichloroisoquinoline (630421-73-7) → C27H23N (1620789-28-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 6 h / 60 °C / Inert atmosphere

2.1: bis(dibenzylideneacetone)-palladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate / toluene; water / 5 h / 130 °C

3.1: potassium tert-butylate / diethyl ether; tetrahydrofuran / 0.5 h / 20 °C

3.2: 16 h / 20 °C

4.1: methanesulfonic acid / dichloromethane / 17 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; methanesulfonic acid; potassium tert-butylate; sodium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; toluene;

Reference yield:

p-tert-butylphenylboronic acid (123324-71-0) → C27H23N (1620789-28-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 6 h / 60 °C / Inert atmosphere

2.1: bis(dibenzylideneacetone)-palladium⁽⁰⁾; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate / toluene; water / 5 h / 130 °C

3.1: potassium tert-butylate / diethyl ether; tetrahydrofuran / 0.5 h / 20 °C

3.2: 16 h / 20 °C

4.1: methanesulfonic acid / dichloromethane / 17 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; methanesulfonic acid; potassium tert-butylate; sodium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; toluene;

upstream raw materials:

1,6-dichloroisoquinoline

p-tert-butylphenylboronic acid

C₁₉H₁₈ClN

C₂₆H₂₃NO

Refernces