stilbene-4,4'-dicarboxylic acid N,N'-bis(3-hydroxypropyl)diamide

Base Information

• Chemical Name: stilbene-4,4'-dicarboxylic acid N,N'-bis(3-hydroxypropyl)diamide
• CAS No.: 166824-90-4
• Molecular Formula: C₂₂H₂₆N₂O₄
• Molecular Weight: 382.459
• Mol file: 166824-90-4.mol

Synonyms:stilbene-4,4'-dicarboxylic acid N,N'-bis(3-hydroxypropyl)diamide

Chemical Property of stilbene-4,4'-dicarboxylic acid N,N'-bis(3-hydroxypropyl)diamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of stilbene-4,4'-dicarboxylic acid N,N'-bis(3-hydroxypropyl)diamide

There total 2 articles about stilbene-4,4'-dicarboxylic acid N,N'-bis(3-hydroxypropyl)diamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Stilbene-4,4'-dicarboxylic acid (100-31-2,133005-88-6,74299-91-5) → stilbene-4,4'-dicarboxylic acid N,N'-bis(3-hydroxypropyl)diamide (166824-90-4)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / dimethylformamide / Heating

2: Et₃N / methanol / 0 - 20 °C

With thionyl chloride; triethylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(01)00760-0

Reference yield:

4,4'-stilbenedicarbonyl dichloride (52238-17-2) + propan-1-ol-3-amine (156-87-6) → stilbene-4,4'-dicarboxylic acid N,N'-bis(3-hydroxypropyl)diamide (166824-90-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; methanol; benzene; Yield given; Ambient temperature;

DOI:10.1021/ja00133a005

Reference yield: 20.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + stilbene-4,4'-dicarboxylic acid N,N'-bis(3-hydroxypropyl)diamide (166824-90-4) → C43H44N2O6 + C64H62N2O8

Guidance literature:

With pyridine; In N,N-dimethyl-formamide; for 3.5h; Ambient temperature;

DOI:10.1021/ja00133a005

upstream raw materials:

4,4'-stilbenedicarbonyl dichloride

propan-1-ol-3-amine

Stilbene-4,4'-dicarboxylic acid

Refernces

• 1、 Letsinger, Robert L.,Wu, Taifeng. "Use of a stilbenedicarboxamide bridge in stabilizing, monitoring, and photochemically altering folded conformations of oligonucleotides". . p. 7323 - 7328. Retrieved 1995.