N-(4-Acetylphenyl)maleamidic acid

Base Information

• Chemical Name: N-(4-Acetylphenyl)maleamidic acid
• CAS No.: 24870-12-0
• Molecular Formula: C12H11 N O4
• Molecular Weight: 233.224
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID901217166
• Nikkaji Number: J800.950C
• Mol file: 24870-12-0.mol

Synonyms:DTXSID901217166;N-(4-Acetylphenyl)maleamidic acid;AKOS000296023;SR-01000196558;(z)-4-(4-acetylphenylamino)-4-oxobut-2-enoic acid;SR-01000196558-1;(2Z)-4-[(4-Acetylphenyl)amino]-4-oxo-2-butenoic acid

Chemical Property of N-(4-Acetylphenyl)maleamidic acid

Chemical Property:

• Vapor Pressure: 2.28E-11mmHg at 25°C
• Melting Point: 206-209oC
• Boiling Point: 513.5°C at 760 mmHg
• Flash Point: 264.3°C
• PSA: 83.47000
• Density: 1.33g/cm³
• LogP: 1.54150
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 233.06880783
• Heavy Atom Count: 17
• Complexity: 340

Purity/Quality:

98%Min ^*data from raw suppliers

4-(4-Acetylanilino)-4-oxo-2-butenoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=CC=C(C=C1)NC(=O)C=CC(=O)O
• Isomeric SMILES: CC(=O)C1=CC=C(C=C1)NC(=O)/C=C\C(=O)O

Technology Process of N-(4-Acetylphenyl)maleamidic acid

There total 4 articles about N-(4-Acetylphenyl)maleamidic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

maleic anhydride (108-31-6) + p-aminobenzophenone (99-92-3) → (Z)-4-(4-acetylphenylamino)-4-oxobut-2-enoic acid (24870-12-0)

Guidance literature:

In ethyl acetate; at 20 ℃; for 3h;

DOI:10.1016/j.jphotobiol.2013.05.005

Reference yield:

fumaryl dichloride (627-63-4) + p-aminobenzophenone (99-92-3) → N-(4-acetyl-phenyl)-maleamic acid (24870-12-0)

Guidance literature:

fumaryl dichloride; p-aminobenzophenone; With sodium hydroxide;

With hydrogenchloride;

DOI:10.1016/j.bmcl.2010.01.098

Reference yield:

maleic anhydride (108-31-6) + p-aminobenzophenone (99-92-3) → N-(4-acetyl-phenyl)-maleamic acid (24870-12-0)

Guidance literature:

upstream raw materials:

maleic anhydride

p-aminobenzophenone

fumaryl dichloride

Downstream raw materials:

Methyl N-(4-acetylphenyl)maleamate

5-(4-acetylphenylimino)-5H-furan-2-one

1-(4-acetylphenyl)-1H-pyrrole-2,5-dione

Refernces

• 1、 Suryanarayana Birudukota,Franke, Raimo,Hofer, Bernd. "An approach to "escape from flatland": Chemo-enzymatic synthesis and biological profiling of a library of bridged bicyclic compounds". . p. 3821 - 3837. Retrieved 2016/05/09.
• 2、 Donya, A. P.,Pakter, M. K.,Sokhina, S. I.. "INFLUENCE OF MEDIUM AND SUBSTITUENTS ON ACYLATION OF AROMATIC AMINES AND THEIR POLYMERIC ANALOGS WITH MALEIC ANHYDRIDE". . p. 2093 - 2097. Retrieved 2007/10/02.