2-(3-Chlorophenyl)acetohydrazide

Base Information

• Chemical Name: 2-(3-Chlorophenyl)acetohydrazide
• CAS No.: 66464-86-6
• Molecular Formula: C8H9ClN2O
• Molecular Weight: 184.625
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID00393727
• Wikidata: Q82192622
• Mol file: 66464-86-6.mol

Synonyms:2-(3-chlorophenyl)acetohydrazide;66464-86-6;3-Chlorophenylacetylhydrazide;3-Chloro-benzeneacetic acid hydrazide;(3-chloro-phenyl)-acetic acid hydrazide;Oprea1_192088;SCHEMBL924347;SCHEMBL8858592;DTXSID00393727;RTQCXLTUAIZZQP-UHFFFAOYSA-N;2-(3-Chlorophenyl)acetic hydrazide;MFCD00245851;STK431256;(3-Chlorophenyl)acetic acid hydrazide;AKOS003306019;MS-7323;3-chlorophenylacetylhydrazide, AldrichCPR;CS-0213268;C78389;A913834

Chemical Property of 2-(3-Chlorophenyl)acetohydrazide

Chemical Property:

• Boiling Point: 394.9 °C at 760 mmHg
• Flash Point: 192.6 °C
• PSA: 55.12000
• Density: 1.283 g/cm³
• LogP: 1.96360
• Storage Temp.: 2-8°C
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 184.0403406
• Heavy Atom Count: 12
• Complexity: 163

Purity/Quality:

99% ^*data from raw suppliers

3-Chlorophenylacetylhydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)Cl)CC(=O)NN

Technology Process of 2-(3-Chlorophenyl)acetohydrazide

There total 6 articles about 2-(3-Chlorophenyl)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2-(3-chlorophenyl)acetic hydrazide hydrochloride → 3-chlorophenylacetic acid hydrazide (66464-86-6)

Guidance literature:

With triethylamine; at 20 ℃; for 0.5h;

DOI:10.1039/d1md00044f

Reference yield: 69.0%

→ 3-chlorophenylacetic acid hydrazide (66464-86-6)

Guidance literature:

With triethylamine; at 20 ℃; for 0.5h; Inert atmosphere;

Reference yield:

methyl 3-chlorophenylacetate (53088-68-9) → 3-chlorophenylacetic acid hydrazide (66464-86-6)

Guidance literature:

With hydrazine; In ethanol; water; for 10h; Reflux;

DOI:10.1155/2017/3687182

upstream raw materials:

ethyl 2-(3-chlorophenyl)acetate

3-chlorophenylacetic acid

methyl 3-chlorophenylacetate

Downstream raw materials:

5-(3-chloro-benzyl)-3H-[1,3,4]oxadiazol-2-one

Refernces

• 1、 Crider, A. Michael,Farr, Susan A.,Frare, Rafael,Hospital, Audrey,Kontoyianni, Maria,Kukielski, Stephen G.,Minaeian, Mahsa,Mobayen, Shirin,Neumann, William L.,Niehoff, Michael L.,Sandoval, Karin E.,Slater, Olivia,Srabony, Khush N.,Witt, Ken A.. "Synthesis and structure-activity relationships of 3,4,5-trisubstituted-1,2,4-triazoles: High affinity and selective somatostatin receptor-4 agonists for Alzheimer's disease treatment". . p. 1352 - 1365. Retrieved 2021/11/09.
• 2、 Vu, Vu Van,Nhung, Trinh Thi,Thanh, Nguyen Thi,Chinh, Luu Van,Tien, Vu Dinh,Thuy, Vu Thu,Thi Thao, Do,Nam, Nguyen Hai,Koeckritz, Angela,Vu, Tran Khac. "Synthesis and Biological Evaluation of New (-)-Gossypol-Derived Schiff Bases and Hydrazones". . . Retrieved 2018/02/28.