(S)(-)-ALPHA-PHENETHYLPHTHALIMIDE

Base Information

• Chemical Name: (S)(-)-ALPHA-PHENETHYLPHTHALIMIDE
• CAS No.: 3976-26-9
• Molecular Formula: C16H13 N O2
• Molecular Weight: 251.285
• Mol file: 3976-26-9.mol

Synonyms:1H-Isoindole-1,3(2H)-dione,2-(1-phenylethyl)-, (S)-; Phthalimide, N-(a-methylbenzyl)-, (S)-(-)- (8CI); (-)-(S)-1-Phenyl-1-phthalamidoethane;(-)-N-(a-Methylbenzyl)phthalimide;(S)-(-)-N-(a-Methylbenzyl)phthalimide

Chemical Property of (S)(-)-ALPHA-PHENETHYLPHTHALIMIDE

Chemical Property:

• PSA: 37.38000
• LogP: 2.98170

Purity/Quality:

99%min ^*data from raw suppliers

(S)(-)-ALPHA-PHENETHYLPHTHALIMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)(-)-ALPHA-PHENETHYLPHTHALIMIDE

There total 20 articles about (S)(-)-ALPHA-PHENETHYLPHTHALIMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-(1-Phenyl-ethyl)-phthalamic acid ethyl ester → 2-(1-phenylethyl)isoindoline-1,3-dione (3976-26-9,6062-39-1,92855-71-5)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 2h; Heating;

DOI:10.1055/s-1998-2038

Reference yield: 96.0%

phthalimide (136918-14-4,85-41-6) + acetophenone p-toluenesulfonylhydrazone (4545-21-5) → 2-(1-phenylethyl)isoindoline-1,3-dione (3976-26-9,6062-39-1,92855-71-5)

Guidance literature:

With copper(l) iodide; caesium carbonate; In 1,4-dioxane; at 110 ℃; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;

DOI:10.1039/c4ra05929h

Reference yield: 95.0%

phthalic anhydride (85-44-9) + (S)-1-phenyl-ethylamine (2627-86-3) → 2-((S)-1-phenylethyl)-isoindoline-1,3-dione (3976-26-9)

Guidance literature:

With triethylamine; In toluene; for 3h; Heating;

DOI:10.3987/com-99-8701

upstream raw materials:

phthalic anhydride

rac-methylbenzylamine

potassium phtalimide

(1-bromoethyl)benzne

Downstream raw materials:

(1'S)-2,3-dihydro-3-hydroxy-3-(pentynyl)-2-(1'-phenylethyl)-1H-isoindol-1-one

rac-methylbenzylamine

Refernces

• 1、 Hoang, Thanh T.,Nguyen, Hanh T.H.,Le, Tien T.,Le, Dung T.,Truong, Thanh,Phan, Nam T.S.. "Amidation via ligand-free direct oxidative C(sp3)-H/N[sbnd]H coupling with Cu-CPO-27 metal-organic framework as a recyclable heterogeneous catalyst". . p. 8241 - 8251. Retrieved 2016/11/23.
• 2、 Wu, Ji-Wei,Wu, Ya-Dong,Dai, Jian-Jun,Xu, Hua-Jian. "Benzoic acid-catalyzed transamidation reactions of carboxamides, phthalimide, ureas and thioamide with amines". supporting information. p. 2429 - 2436. Retrieved 2014/09/30.