1-Benzyl-3-aminopiperidine

Base Information

• Chemical Name: 1-Benzyl-3-aminopiperidine
• CAS No.: 60407-35-4
• Molecular Formula: C12H18N2
• Molecular Weight: 190.288
• Hs Code.: 29333990
• Mol file: 60407-35-4.mol

Synonyms:1-Benzyl-3-aminopiperidine;3-Amino-1-benzylpiperidine;

Chemical Property of 1-Benzyl-3-aminopiperidine

Chemical Property:

• Vapor Pressure: 3.42E-05mmHg at 25°C
• Boiling Point: 281.153 °C at 760 mmHg
• PKA: 10.21±0.20(Predicted)
• Flash Point: 113.886 °C
• PSA: 29.26000
• Density: 1.038 g/cm³
• LogP: 3.85190
• Storage Temp.: 0-10°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Benzylpiperidin-3-amine ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Benzyl-3-aminopiperidine

There total 14 articles about 1-Benzyl-3-aminopiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.3%

3-(N-acetamino)-1-benzylpiperidine (60169-74-6) → 1-phenylmethyl-3-aminopiperidine (60407-35-4)

Guidance literature:

With hydrogenchloride; In water; for 1h; Reflux;

Reference yield: 91.0%

(1-benzylpiperidin-3-yl)carbamic acid tert-butyl ester (478828-62-5,216854-24-9) → 1-phenylmethyl-3-aminopiperidine (60407-35-4)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 24h;

DOI:10.1016/j.ejmech.2016.09.078

Reference yield: 86.0%

(±)-1-benzylpiperidine-3-carbohydrazide (182919-58-0) → 1-phenylmethyl-3-aminopiperidine (60407-35-4)

Guidance literature:

With trifluoroacetic acid; sodium nitrite; In water; at 0 - 80 ℃; for 4h;

DOI:10.1016/j.ejmech.2016.11.006

upstream raw materials:

(±)-1-benzylpiperidine-3-carbohydrazide

benzyl bromide

ethyl 1-benzylpiperidine-3-carboxylate

benzyl chloride

Downstream raw materials:

2-hydroxy-N-(1-methylpiperidin-3-yl)-2,2-diphenylacetamide

C₂₇H₃₆N₆O₂

Refernces

• 1、 Abdelrahman, Mostafa H.,Youssif, Bahaa G.M.,abdelgawad, Mohamed A.,Abdelazeem, Ahmed H.,Ibrahim, Hussein M.,Moustafa, Abd El Ghany A.,Treamblu, Laurent,Bukhari, Syed Nasir Abbas. "Synthesis, biological evaluation, docking study and ulcerogenicity profiling of some novel quinoline-2-carboxamides as dual COXs/LOX inhibitors endowed with anti-inflammatory activity". . p. 972 - 985. Retrieved 2017/02/13.
• 2、 -. "NOVEL COMPOUNDS AS ANTI-TUBERCULAR AGENTS". . . Retrieved 2015/12/17.