C₂₀H₁₉BrFN₃O₄

Base Information

• Chemical Name: C₂₀H₁₉BrFN₃O₄
• CAS No.: 1374233-70-1
• Molecular Formula: C₂₀H₁₉BrFN₃O₄
• Molecular Weight: 464.291
• Mol file: 1374233-70-1.mol

Synonyms:C₂₀H₁₉BrFN₃O₄

Chemical Property of C₂₀H₁₉BrFN₃O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₁₉BrFN₃O₄

There total 3 articles about C₂₀H₁₉BrFN₃O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

C10H14BrN3O2 (1374233-69-8) + 2-bromo-3-(4-fluorophenyl)-3-oxopropionic acid methyl ester (1001922-15-1) → C20H19BrFN3O4 (1374233-70-1)

Guidance literature:

C₁₀H₁₄BrN₃O₂; 2-bromo-3-(4-fluorophenyl)-3-oxopropionic acid methyl ester; In N,N-dimethyl-formamide; at 80 ℃; for 42h; Inert atmosphere;

With sodium hydrogencarbonate; In water; N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

Reference yield:

methyl 2-amino-5-bromo-pyridine-4-carboxylate (882499-87-8) → C20H19BrFN3O4 (1374233-70-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 70 °C / Inert atmosphere

1.2: 0 °C / pH 6

2.1: diphenyl phosphoryl azide; triethylamine / 6 h / 90 °C / Inert atmosphere

3.1: N,N-dimethyl-formamide / 42 h / 80 °C / Inert atmosphere

3.2: 0.25 h / 0 °C

With diphenyl phosphoryl azide; water; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

C6H5BrN2O2 (1000339-23-0) → C20H19BrFN3O4 (1374233-70-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diphenyl phosphoryl azide; triethylamine / 6 h / 90 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide / 42 h / 80 °C / Inert atmosphere

2.2: 0.25 h / 0 °C

With diphenyl phosphoryl azide; triethylamine; In N,N-dimethyl-formamide;

upstream raw materials:

methyl 2-amino-5-bromo-pyridine-4-carboxylate

C₁₀H₁₄BrN₃O₂

2-bromo-3-(4-fluorophenyl)-3-oxopropionic acid methyl ester

C₆H₅BrN₂O₂

Downstream raw materials:

C₁₅H₁₁BrFN₃O₂

C₁₇H₁₅BrFN₃O₆S₂

C₁₆H₁₃BrFN₃O₄S

C₂₁H₂₁BrFN₃O₄S

Refernces