ethyl endo-bicyclo<5.1.0>octane-8-carboxylate

Base Information

• Chemical Name: ethyl endo-bicyclo<5.1.0>octane-8-carboxylate
• CAS No.: 55449-84-8
• Molecular Formula: C₁₁H₁₈O₂
• Molecular Weight: 182.263
• Mol file: 55449-84-8.mol

Synonyms:ethyl endo-bicyclo<5.1.0>octane-8-carboxylate

Chemical Property of ethyl endo-bicyclo<5.1.0>octane-8-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl endo-bicyclo<5.1.0>octane-8-carboxylate

There total 1 articles about ethyl endo-bicyclo<5.1.0>octane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diazoacetic acid ethyl ester (623-73-4) + Cycloheptene (628-92-2,45509-99-7) → ethyl endo-bicyclo<5.1.0>octane-8-carboxylate (55449-84-8) + diethyl Fumarate (623-91-6) + Diethyl maleate (141-05-9)

Guidance literature:

ruthenacarborane 1; at 60 ℃; for 4h;

DOI:10.1016/0040-4039(92)88126-P

Reference yield:

ethyl (1R,7S)-bicyclo[5.1.0]octane-8-carboxylate (4729-32-2,4729-45-7,55449-84-8) → (1R,2S)-2-(2-oxoethyl)cycloheptyl 2-nitrobenzoate + (1S,2R)-2-(2-oxoethyl)cycloheptyl 2-nitrobenzoate

Guidance literature:

Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / diethyl ether / 1 h / 0 °C / Inert atmosphere

2: pyridinium chlorochromate / dichloromethane / 1 h / 20 °C / Inert atmosphere

3: (S)-2-(bis(3,5-bis(trifluoromethyl)phenyl)((methyldiphenylsilyl)oxy)methyl)pyrrolidine / m-xylene / 48 h / 80 °C

With lithium aluminium tetrahydride; (S)-2-(bis(3,5-bis(trifluoromethyl)phenyl)((methyldiphenylsilyl)oxy)methyl)pyrrolidine; pyridinium chlorochromate; In diethyl ether; dichloromethane; m-xylene;

DOI:10.1002/chem.201801434

upstream raw materials:

diazoacetic acid ethyl ester

Cycloheptene

Refernces