1H-Indazole-5-carbaldehyde

Base Information

• Chemical Name: 1H-Indazole-5-carbaldehyde
• CAS No.: 253801-04-6
• Molecular Formula: C8H6N2O
• Molecular Weight: 146.148
• Hs Code.: 2933990090
• Mol file: 253801-04-6.mol

Synonyms:ZINC08700340;

Chemical Property of 1H-Indazole-5-carbaldehyde

Chemical Property:

• Vapor Pressure: 2.56E-05mmHg at 25°C
• Melting Point: 115-119°C
• Refractive Index: 1.747
• Boiling Point: 358.3 °C at 760 mmHg
• PKA: 12.87±0.40(Predicted)
• Flash Point: 174.4 °C
• PSA: 45.75000
• Density: 1.369 g/cm³
• LogP: 1.37540
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

1H-Indazole-5-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indazole-5-carbaldehyde

There total 12 articles about 1H-Indazole-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-hydroxymethyl-1H-indazole (478828-52-3) → 1H-indazole-5-carbaldehyde (253801-04-6)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; for 12h;

Reference yield: 59.0%

carbon monoxide (201230-82-2) + 5-iodo-1H-indazole (55919-82-9) + sodium formate (141-53-7) → 1H-indazole-5-carbaldehyde (253801-04-6)

Guidance literature:

bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 110 ℃; for 6h;

Reference yield: 58.0%

5-bromo-1H-indazole (53857-57-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 1H-indazole-5-carbaldehyde (253801-04-6)

Guidance literature:

5-bromo-1H-indazole; With n-butyllithium; In tetrahydrofuran; at -50 ℃; for 2h;

N,N-dimethyl-formamide; In tetrahydrofuran; for 0.5h;

upstream raw materials:

5-bromo-1H-indazole

N,N-dimethyl-formamide

1H-indazole-5-carbonitrile

5-hydroxymethyl-1H-indazole

Downstream raw materials:

(1H-indazol-5-yl)(phenyl)methanol

(E)-1-(3-chlorophenyl)-3-(1H-indazol-5-yl)prop-2-en-1-one

(E)-N-(3-chloro-4-fluorophenyl)-1-(1H-indazol-5-yl)methanimine

(E)-N-(4-chloro-3-fluorophenyl)-1-(1H-indazol-5-yl)methanimine

Refernces

• 1、 -. "Imidazole derivative containing indazole structure as well as preparation method and application thereof". Page/Page column 21. . Retrieved 2021/01/28.
• 2、 Sheppeck II, James E.,Gilmore, John L.,Xiao, Hai-Yun,Dhar, T.G. Murali,Nirschl, David,Doweyko, Arthur M.,Sack, Jack S.,Corbett, Martin J.,Malley, Mary F.,Gougoutas, Jack Z.,McKay, Lorraine,Cunningham, Mark D.,Habte, Sium F.,Dodd, John H.,Nadler, Steven G.,Somerville, John E.,Barrish, Joel C.. "Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists". . p. 5442 - 5447. Retrieved 2013/09/23.