(S)-3-butyn-2-ol hydrogen phthalate (S)-α-methylbenzylammonium salt

Base Information

• Chemical Name: (S)-3-butyn-2-ol hydrogen phthalate (S)-α-methylbenzylammonium salt
• CAS No.: 100837-08-9
• Molecular Formula: C₈H₁₁N*C₁₂H₁₀O₄
• Molecular Weight: 339.391
• Mol file: 100837-08-9.mol

Synonyms:(S)-3-butyn-2-ol hydrogen phthalate (S)-α-methylbenzylammonium salt

Chemical Property of (S)-3-butyn-2-ol hydrogen phthalate (S)-α-methylbenzylammonium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-butyn-2-ol hydrogen phthalate (S)-α-methylbenzylammonium salt

There total 5 articles about (S)-3-butyn-2-ol hydrogen phthalate (S)-α-methylbenzylammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

(S)-1-phenyl-ethylamine (2627-86-3) + Phthalic acid mono-(1-methyl-prop-2-ynyl) ester (3113-93-7,3113-94-8,42969-62-0,100837-07-8) → (S)-3-butyn-2-ol hydrogen phthalate (S)-α-methylbenzylammonium salt (100837-08-9)

Guidance literature:

In acetone; for 0.5h; Heating;

DOI:10.1016/S0223-5234(99)80018-X

Reference yield:

phthalic anhydride (85-44-9) → (S)-3-butyn-2-ol hydrogen phthalate (S)-α-methylbenzylammonium salt (100837-08-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / aq. NaOH / 0.08 h

2: acetone / 0.5 h / Heating

With sodium hydroxide; In acetone;

DOI:10.1021/jm00403a012

Reference yield:

phthalic anhydride (85-44-9) → (S)-3-butyn-2-ol hydrogen phthalate (S)-α-methylbenzylammonium salt (100837-08-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / aq. NaOH / 0.08 h / 0 °C

2: 32 percent / acetone / 0.5 h / Heating

With sodium hydroxide; In acetone;

DOI:10.1016/S0223-5234(99)80018-X

upstream raw materials:

(S)-1-phenyl-ethylamine

(+/-)-but-3'-yn-2'-yl hydrogen phthalate

Phthalic acid mono-(1-methyl-prop-2-ynyl) ester

phthalic anhydride

Downstream raw materials:

(S)-3-butyn-2-ol hydrogen phthalate

Refernces

• 1、 Cotterill, Ann S.,Gill, Melvyn,Gimenez, Alberto,Milanovic Nives M.. "Pigments of Fungi. Part 38. Synthesis of Austrocorticinic Acid and (S)-(-)-Austrocorticin; Absolute Stereochemistry of Natural Austrocorticin". . p. 3269 - 3276. Retrieved 2007/10/02.