4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE HYDROCHLORIDE

Base Information

• Chemical Name: 4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE HYDROCHLORIDE
• CAS No.: 28783-38-2
• Molecular Formula: C7H9NS·ClH
• Molecular Weight: 175.682
• Hs Code.: 2934999090
• Mol file: 28783-38-2.mol

Synonyms:Thieno[2,3-c]pyridine,4,5,6,7-tetrahydro-, hydrochloride (8CI,9CI);4,5,6,7-Tetrahydrothieno[2,3-c]pyridine hydrochloride (1:1);4,5,6,7-Tetrahydrothieno[2,3-c]pyridinhydrochlorid;4,5,6,7-Tetrahydrothieno[2,3-c]pyridine HCl;TL80073586;MFCD08448167;

Chemical Property of 4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.00331mmHg at 25°C
• Boiling Point: 278.3 °C at 760 mmHg
• Flash Point: 122.1 °C
• PSA: 40.27000
• LogP: 2.52460
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: DMSO, Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

4,5,6,7-Tetrahydrothieno[2,3-c]pyridine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4,5,6,7-Tetrahydrothieno[2,3-c]pyridine hydrochloride is used for preparation of thieno-tetrahydropyridines useful as class III antiarrhythmic agents.

Technology Process of 4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE HYDROCHLORIDE

There total 1 articles about 4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(tert-butoxycarbonyl)-4,5,6,7-tetrahydro-6H-thieno[2,3-c]pyridine (165947-52-4) → 4,5,6,7-tetrahydrothieno[2,3-c]pyridine hydrochloride (28783-38-2)

Guidance literature:

With hydrogenchloride; In methanol;

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + 4,5,6,7-tetrahydrothieno[2,3-c]pyridine hydrochloride (28783-38-2) → 6-(tert-butoxycarbonyl)-4,5,6,7-tetrahydro-6H-thieno[2,3-c]pyridine (165947-52-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 4.5h;

Reference yield: 90.0%

4,5,6,7-tetrahydrothieno[2,3-c]pyridine hydrochloride (28783-38-2) + (S)-1-phenyl-2-(tosyloxy)ethanol (40435-14-1) → (S)-2-(4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)-1-phenylethanol

Guidance literature:

With triethylamine; at 80 ℃; for 4h;

DOI:10.14233/ajchem.2020.22881

upstream raw materials:

6-(tert-butoxycarbonyl)-4,5,6,7-tetrahydro-6H-thieno[2,3-c]pyridine

Downstream raw materials:

2-bromo-4,5,6,7-tetrahydrothieno[2,3-c]pyridine hydrobromide

6-(tert-butoxycarbonyl)-4,5,6,7-tetrahydro-6H-thieno[2,3-c]pyridine

(S)-(+)-clopidogrel

Refernces