3-CHLORO-2-HYDROXY-BENZALDEHYDE

Base Information

• Chemical Name: 3-CHLORO-2-HYDROXY-BENZALDEHYDE
• CAS No.: 1927-94-2
• Molecular Formula: C7H5ClO2
• Molecular Weight: 156.569
• Hs Code.: 2913000090
• Mol file: 1927-94-2.mol

Synonyms:Salicylaldehyde,3-chloro- (6CI,7CI,8CI);2-Chloro-6-formylphenol;2-Hydroxy-3-chlorobenzaldehyde;3-Chloro-2-hydroxybenzaldehyde;3-Chlorosalicylaldehyde;

Chemical Property of 3-CHLORO-2-HYDROXY-BENZALDEHYDE

Chemical Property:

• Appearance/Colour: yellow solid
• Vapor Pressure: 0.188mmHg at 25°C
• Melting Point: 42-44°C
• Refractive Index: 1.632
• Boiling Point: 204.1°Cat760mmHg
• PKA: 6.70±0.10(Predicted)
• Flash Point: 110℃
• PSA: 37.30000
• Density: 1.404g/cm³
• LogP: 1.85810
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility.: Acetone (Slightly), Chloroform (Slightly), Dichloromethane (Slightly), DMSO(Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Chlorosalicylaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Chlorosalicylaldehyde (cas# 1927-94-2) is a compound useful in organic synthesis.

Technology Process of 3-CHLORO-2-HYDROXY-BENZALDEHYDE

There total 27 articles about 3-CHLORO-2-HYDROXY-BENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-monochlorophenol (95-57-8) → 3-chlorosalicylaldehyde (1927-94-2)

Guidance literature:

With triethylamine; magnesium chloride; In acetonitrile; for 3.5h; Heating;

DOI:10.3891/acta.chem.scand.53-0258

Reference yield: 87.0%

salicylaldehyde (90-02-8) → 3-chlorosalicylaldehyde (1927-94-2)

Guidance literature:

With 2,2,6,6-tetramethyl-piperidine; sulfuryl dichloride; at 100 ℃; for 0.5h; Solvent; Temperature; regioselective reaction; Inert atmosphere;

DOI:10.1021/jo402424h

Reference yield: 70.0%

2-monochlorophenol (95-57-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-chlorosalicylaldehyde (1927-94-2)

Guidance literature:

N,N-dimethyl-formamide; With trichlorophosphate; In acetonitrile; at -5 ℃; for 1h;

2-monochlorophenol; With copper(II) nitrate; In acetonitrile; at 20 ℃; for 18h;

With water; In acetonitrile; Reagent/catalyst; Time; Solvent; Temperature; Kinetics; Mechanism; Catalytic behavior; Heating;

DOI:10.1007/s10953-016-0442-5

upstream raw materials:

chloral hydrate

2-monochlorophenol

2-chloro-6-(hydroxymethyl)phenol

sodium 3-nitrobenzenesulfonate

Downstream raw materials:

3-Chlorocatechol

8-chloro-2-phenyl-4H-chromen-4-one

C₂₉H₃₇ClN₂O₂

Refernces

• 1、 Bouchmaa, Najat,Ben Mrid, Reda,Boukharsa, Youness,Nhiri, Mohamed,Ait Mouse, Hassan,Taoufik, Jamal,Ansar, M'hammed,Zyad, Abdelmajid. "Cytotoxicity of new pyridazin-3(2H)-one derivatives orchestrating oxidative stress in human triple-negative breast cancer (MDA-MB-468)". . . Retrieved 2018/11/02.
• 2、 Chen, Wei,Zhou, Zhao-Hui,Chen, Hong-Bin. "Efficient synthesis of chiral benzofuryl β-amino alcohols via a catalytic asymmetric Henry reaction". supporting information. p. 1530 - 1536. Retrieved 2017/02/15.